Anti-PIK3C3 Antibody

ArtNr	BOS-A02356
Hersteller	Boster
Menge	0.1 mg
Kategorie	Oncology By Cell Type Cell Biology Cell Status Western Blot ELISA Autophagy Cardiovascular Research Myocardial Infarction Immunostaining
Format	Liquid
Applikationen	WB, ELISA
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus), Rat (Rattus norvegicus)
Host	Rabbit
Isotype	IgG
Alias	VPS34,hVps34,VPS34,Phosphatidylinositol 3-kinase catalytic subunit type 3,Phosphatidylinositol 3-kinase p100 subunit,PI3-kinase type 3
Lieferbar
Manufacturer - Category	Primary Antibodies
Storage Conditions	PIK3C3 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.
Molecular Weight	101549 MW
Clonality	Polyclonal
Application Details	PIK3C3 antibody can be used for detection of PIK3C3 by Western blot at 1 - 2 μg/ml. Antibody validated: Western Blot in mouse samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Gene Name	PIK3C3
Gene Full Name	Phosphatidylinositol 3-kinase, catalytic subunit type 3
Manufacturer - Specificity	PIK3C3 antibody is human, mouse and rat reactive.
Background	PI 3-kinase p100 (phosphoinositide-3-kinase p100 subunit), also known as hVps34 or PIK3C3 (phosphoinositide-3-kinase class III), is a member of the PI3/PI4-kinase family (1). It is a catalytic subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate and ubiquitously expressed with a highest expression in skeletal muscle (1, 2). PIK3C3 is involved in the endosome to lysosome transport and plays important roles in intracellular membrane trafficking and autophagy (3-5).
Immunogen	PIK3C3 antibody was raised against an 18 amino acid peptide near the amino terminus of human PIK3C3. The immunogen is located within amino acids 130 - 180 of PIK3C3.
Contents	PIK3C3 antibody is supplied in PBS containing 0.02% sodium azide.
Purification	PIK3C3 antibody is affinity chromatography purified via peptide column.
Concentration	1 mg/mL
Manufacturer - Research Category	Autophagy
Protein Name	Phosphatidylinositol 3-kinase, catalytic subunit type 3
Protein Function	Catalytic subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2 (PubMed:20643123, PubMed:20208530). Involved in the transport of lysosomal enzyme precursors to lysosomes. Required for transport from early to late endosomes (By similarity).
Subcellular Localization	Midbody
Description	Boster Bio Anti-PIK3C3 Antibody (Catalog # A02356). Tested in ELISA, WB applications. This antibody reacts with Human, Mouse, Rat.
Tissue Specificity	Ubiquitously expressed, with a highest expression in skeletal muscle.
Predicted Reactivity	Pig
Manufacturer - Cross Reactivity	PIK3C3 antibody is human, mouse and rat reactive.

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BOS-A02356-datasheet.pdf

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