Anti-GPR41 FFAR3 Antibody

Primary Antibodies

38649 MW

WB: 1:500-1:1000
IF: 1:50-1:200

Free fatty acid receptor 3

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

1 mg/ml

G protein-coupled receptor that is activated by a major
product of dietary fiber digestion, the short chain fatty acids
(SCFAs), and that plays a role in the regulation of whole-body
energy homeostasis and in intestinal immunity. In omnivorous
mammals, the short chain fatty acids acetate, propionate and
butyrate are produced primarily by the gut microbiome that
metabolizes dietary fibers. SCFAs serve as a source of energy but
also act as signaling molecules. That G protein-coupled receptor
is probably coupled to the pertussis toxin-sensitive, G (i/o)-alpha
family of G proteins. Its activation results in the formation of
inositol 1, 4, 5-trisphosphate, the mobilization of intracellular
calcium, the phosphorylation of the MAPK3/ERK1 and MAPK1/ERK2
kinases and the inhibition of intracellular cAMP accumulation
(PubMed:12711604). Activated by SCFAs and by beta-hydroxybutyrate,
a ketone body produced by the liver upon starvation, it inhibits
N-type calcium channels and modulates the activity of sympathetic
neurons through a signaling cascade involving the beta and gamma
subunits of its coupled G protein, phospholipase C and MAP
kinases. Thereby, it may regulate energy expenditure through the
control of the sympathetic nervous system that controls for
instance heart rate. Upon activation by SCFAs accumulating in the
intestine, it may also signal to the brain via neural circuits
which in turn would regulate intestinal gluconeogenesis. May also
control the production of hormones involved in whole-body energy
homeostasis. May for instance, regulate blood pressure through
renin secretion. May also regulate secretion of the PYY peptide by
enteroendocrine cells and control gut motility, intestinal transit
rate, and the harvesting of energy from SCFAs produced by gut
microbiota. May also indirectly regulate the production of
LEP/Leptin, a hormone acting on the CNS to inhibit food intake, in
response to the presence of short-chain fatty acids in the
intestine. Finally, may also play a role in glucose homeostasis.
Besides its role in energy homeostasis, may play a role in
intestinal immunity. May mediate the activation of the
inflammatory and immune response by SCFAs in the gut, regulating
the rapid production of chemokines and cytokines by intestinal
epithelial cells. Among SCFAs, the fatty acids containing less
than 6 carbons, the most potent activators are probably
propionate, butyrate and pentanoate while acetate is a poor
activator (PubMed:12496283, PubMed:12711604).

Boster Bio Anti-GPR41 FFAR3 Antibody catalog # A02437-1. Tested in WB, IF applications. This antibody reacts with Human, Mouse, Rat.