Anti-LPIN1 Antibody

ArtNr	BOS-A02467
Hersteller	Boster
Menge	0.1 mg
Kategorie	Metabolism Cholesterol & Lipid Metabolism Obesity Immunohistochemistry Western Blot ELISA Immunofluorescence Enzymes Other Fatty Acid Enzymes Immunostaining
Format	Liquid
Applikationen	WB, IF, ELISA, IHC-P
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus), Rat (Rattus norvegicus)
Host	Rabbit
Isotype	IgG
Alias	PAP1,KIAA0188,Phosphatidate phosphatase LPIN1,Lipin-1
Lieferbar
Manufacturer - Category	Primary Antibodies
Storage Conditions	LPIN antibody can be stored at 4°C for three months and -20°C, stable for up to one year.
Molecular Weight	98664 MW
Clonality	Polyclonal
Application Details	LPIN1 antibody can be used for detection of LPIN1 by Western blot at 1 - 2 μg/mL. Antibody validated: Western Blot in human samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Gene Name	LPIN1
Gene Full Name	Lipin 1
Manufacturer - Specificity	LPIN1 antibody is human and mouse reactive. At least four isoforms of LPIN1 are known to exist.
Background	LPIN1, also known as PAP1, is a magnesium-ion-dependent phosphatidic acid phosphohydrolase enzyme that catalyzes the penultimate step in triglyceride synthesis including the dephosphorylation of phosphatidic acid to yield diacylglycerol (reviewed in 1). LPIN1 is required for adipocyte differentiation and it also functions as a nuclear transcriptional coactivator with some peroxisome proliferator-activated receptors to modulate expression of other genes involved in lipid metabolism (1, 2). Mutations in LPIN1 are associated with metabolic diseases such as type 2 diabetes and recurrent acute myoglobinuria (3, 4) and it is also a candidate for several human lipodystrophy syndromes (5).
Immunogen	LPIN1 antibody was raised against an 18 amino acid peptide near the carboxy terminus of human LPIN1. The immunogen is located within the last 50 amino acids of LPIN1.
Contents	LPIN Antibody is supplied in PBS containing 0.02% sodium azide.
Purification	LPIN1 Antibody is affinity chromatography purified via peptide column.
Concentration	1 mg/mL
Manufacturer - Research Category	Stem Cells
Protein Name	Lipin 1
Protein Function	Plays important roles in controlling the metabolism of fatty acids at different levels. Acts as a magnesium-dependent phosphatidate phosphatase enzyme which catalyzes the conversion of phosphatidic acid to diacylglycerol during triglyceride, phosphatidylcholine and phosphatidylethanolamine biosynthesis in the reticulum endoplasmic membrane. Acts also as a nuclear transcriptional coactivator for PPARGC1A/PPARA to modulate lipid metabolism gene expression (By similarity). Is involved in adipocyte differentiation. May also be involved in mitochondrial fission by converting phosphatidic acid to diacylglycerol (By similarity).
Subcellular Localization	Nucleus membrane. Cytoplasm, cytosol. Endoplasmic reticulum membrane.
Description	Boster Bio Anti-LPIN1 Antibody (Catalog # A02467). Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse, Rat.
Tissue Specificity	Specifically expressed in skeletal muscle. Also abundant in adipose tissue. Lower levels in some portions of the digestive tract.
Manufacturer - Cross Reactivity	LPIN1 antibody is human and mouse reactive. At least four isoforms of LPIN1 are known to exist.

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BOS-A02467-datasheet.pdf

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