Anti-HCAR2 Antibody

ArtNr	BOS-A02511
Hersteller	Boster
Menge	100 ul
Kategorie	Metabolism Cholesterol & Lipid Metabolism Immunohistochemistry Western Blot Immunofluorescence Immunocytochemistry Immunochemistry Other Lipid\Cholesterol Metabolism Modulators
Format	Liquid
Applikationen	WB, IF, IHC, ICC
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus), Rat (Rattus norvegicus)
Host	Rabbit
Alias	Hydroxycarboxylic acid receptor 2,G-protein coupled receptor 109A,G-protein coupled receptor HM74A,Niacin receptor 1,Nicotinic acid receptor,HCAR2,GPR109A,HCA2,HM74A,NIACR1
Lieferbar
Manufacturer - Category	Primary Antibodies
Storage Conditions	Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Molecular Weight	41850 MW
Clonality	Polyclonal
Application Details	WB: 1:500-1:2000 IHC: 1:50-1:200 ICC/IF: 1:50-1:200
Gene Name	HCAR2
Gene Full Name	Hydroxycarboxylic acid receptor 2
Immunogen	A synthetic peptide of human GPR109A/HM74A/HCAR2(NP_808219.1).
Contents	Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Concentration	1 mg/ml
Protein Name	Hydroxycarboxylic acid receptor 2
Protein Function	Acts as a high affinity receptor for both nicotinic acid (also known as niacin) and (D)-beta-hydroxybutyrate and mediates increased adiponectin secretion and decreased lipolysis through G (i)-protein-mediated inhibition of adenylyl cyclase. This pharmacological effect requires nicotinic acid doses that are much higher than those provided by a normal diet. Mediates nicotinic acid-induced apoptosis in mature neutrophils. Receptor activation by nicotinic acid results in reduced cAMP levels which may affect activity of cAMP-dependent protein kinase A and phosphorylation of target proteins, leading to neutrophil apoptosis. The rank order of potency for the displacement of nicotinic acid binding is 5- methyl pyrazole-3-carboxylic acid = pyridine-3-acetic acid > acifran > 5-methyl nicotinic acid = acipimox >> nicotinuric acid = nicotinamide.
Subcellular Localization	Cell membrane
Description	Boster Bio Anti-HCAR2 Antibody catalog # A02511. Tested in WB, IHC, ICC/IF applications. This antibody reacts with Human, Mouse, Rat.
Tissue Specificity	Expression largely restricted to adipose tissue and spleen. Expressed on mature neutrophils but not on immature neutrophils or eosinophils.

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Arbeitsanleitung (Data Sheet) anfordern

BOS-A02511-datasheet.pdf

BOS-A02511-safety-datasheet.pdf