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Anti-CaMKII alpha/CAMK2A Antibody Picoband®

Anti-CaMKII alpha/CAMK2A Antibody Picoband®

ArtNr	BOS-A03241-2-iFluor647
Hersteller	Boster
Menge	100 ug
Quantity options	100 ug/vial 10 ug 100 ug 100 ug 100 ug 100 ug 100 ug 100 ug 100 ug 100 ug 100 ug 100 ug
Kategorie	Neuroscience Neural Lineage Markers Molecular Targets for Neuroscience Neural Adhesion Molecules Antibodies Flow Cytometry Western Blot ELISA Immunofluorescence Immunocytochemistry Primary Antibodies Immunostaining Stem Cell Markers Immunochemistry
Typ	Primary Antibody
Format	Lyophilized
Applikationen	WB, FC, IF, ICC, ELISA
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus), Rat (Rattus norvegicus)
Host	Rabbit
Isotype	IgG
Sensitivity	>5000 cells
Citations	1. Akita, T., Aoto, K., Kato, M., Shiina, M., Mutoh, H., Nakashima, M., Kuki, I., Okazaki, S., Magara, S., Shiihara, T., Yokochi, K., Aiba, K., Tohyama, J., Ohba, C., Miyatake, S., Miyake, N., Ogata, K., Fukuda, A., Matsumoto, N., Saitsu, H. De novo variants in CAMK2A and CAMK2B cause neurodevelopmental disorders. Ann. Clin. Transl. Neurol. 5: 280-296, 2018. 2. Bayer, K.-U., De Koninck, P., Leonard, A. S., Hell, J. W., Schulman, H. Interaction with the NMDA receptor locks CaMKII in an active conformation. Nature 411: 801-805, 2001. 3. Chen, C., Rainnie, D. G., Greene, R. W., Tonegawa, S. Abnormal fear response and aggressive behavior in mutant mice deficient for alpha-calcium-calmodulin kinase II. Science 266: 291-294, 1994.
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	Calcium/calmodulin-dependent protein kinase type II subunit alpha,CaM kinase II subunit alpha,CaMK-II subunit alpha,CAMK2A,CAMKA,KIAA0968
Lieferbar
Manufacturer - Category	Primary Antibodies
Manufacturer - Conjugate / Tag	iFluor647
Storage Conditions	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
Observed Molecular weight	54 kDa
Clonality	Polyclonal
Application Details	Western blot, 0.25-0.5μg/ml, Mouse, Rat Immunocytochemistry/Immunofluorescence, 5μg/ml, Human Immunofluorescence, 5μg/ml, Rat Flow Cytometry (Fixed), 1-3μg/1x10⁶ cells, Human, Mouse, Rat ELISA, 0.1-0.5μg/ml
Gene Name	CAMK2A
Gene Full Name	calcium/calmodulin dependent protein kinase II alpha
Manufacturer - Specificity	No cross reactivity with other proteins.
Background	Calcium/calmodulin-dependent protein kinase type II subunit alpha (CAMKIIα ), a.k.a. Ca2+/calmodulin-dependent protein kinase II alpha, is a protein kinase (i.e., an enzyme which phosphorylates proteins) that in humans is encoded by the CAMK2A gene. It is mapped to 5q32. The product of this gene belongs to the serine/threonine protein kinases family, and to the Ca (2+)/calmodulin-dependent protein kinases subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. This calcium calmodulin-dependent protein kinase is composed of four different chains: alpha, beta, gamma, and delta. The alpha chain encoded by this gene is required for hippocampal long-term potentiation (LTP) and spatial learning. In addition to its calcium-calmodulin (CaM)-dependent activity, this protein can undergo autophosphorylation, resulting in CaM-independent activity. Several transcript variants encoding distinct isoforms have been identified for this gene.
Immunogen	E.coli-derived human CaMKII alpha/CAMK2A recombinant protein (Position: M1-H478).
Contents	Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na₂HPO₄, 0.05mg NaN₃.
Purification	Immunogen affinity purified.
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.
Manufacturer - Research Category	Calcium Signaling, Calmodulin Pathway, Cardiovascular, Hypertrophy, Neuroscience, Neurotransmission, Protein Phosphorylation, Ser/Thr Kinases, Signal Transduction, Signaling Pathway
Protein Function	Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca2+/calmodulin-binding and autophosphorylation, and is involved in synaptic plasticity, neurotransmitter release and long-term potentiation. Member of the NMDAR signaling complex in excitatory synapses, it regulates NMDAR-dependent potentiation of the AMPAR and therefore excitatory synaptic transmission. Regulates dendritic spine development. Also regulates the migration of developing neurons. Phosphorylates the transcription factor FOXO3 to activate its transcriptional activity.
Subcellular Localization	Synapse. Postsynaptic density. Dendritic spine. Dendrite.
Description	Boster Bio Anti-CaMKII alpha/CAMK2A Antibody Picoband® catalog # A03241-2. Tested in ELISA, Flow Cytometry, IF, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Tissue Specificity	High levels found in the brain, heart and lung while lower levels are seen in the liver, kidney and skeletal muscle.
Manufacturer - Cross Reactivity	No cross-reactivity with other proteins.

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BOS-A03241-2-iFluor647-datasheet.pdf

BOS-A03241-2-iFluor647-safety-datasheet.pdf