ArtNr |
BOS-A04529-2-Cy3 |
Hersteller |
Boster
|
Menge |
100 ug |
Format |
Lyophilized |
Applikationen |
WB, ELISA |
Specific against |
Human (Homo sapiens), Mouse (Murine, Mus musculus), Rat (Rattus norvegicus) |
Host |
Rabbit |
Isotype |
IgG |
Konjugat/Tag |
Cy3 |
Sensitivity |
>5000 cells |
Citations |
1. Kajiwara, M., Terada, T., Ogasawara, K., Iwano, J., Katsura, T., Fukatsu, A., Doi, T., Inui, K. Identification of multidrug and toxin extrusion (MATE1 and MATE2-K) variants with complete loss of transport activity. J. Hum. Genet. 54: 40-46, 2009. 2. Otsuka, M., Matsumoto, T., Morimoto, R., Arioka, S., Omote, H., Moriyama, Y. A human transporter protein that mediates the final excretion step for toxic organic cations. Proc. Nat. Acad. Sci. 102: 17923-17928, 2005. |
Alias |
Ras-related protein Rab-11B; GTP-binding protein YPT3; RAB11B; YPT3 |
Lieferbar |
|
Manufacturer - Category |
Primary Antibodies |
Manufacturer - Isotype |
Rabbit IgG |
Storage Conditions |
At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months.Avoid repeated freezing and thawing. |
Observed Molecular Weight |
32 kDa |
Clonality |
Polyclonal |
Application Details |
Western blot, 0.25-0.5 μg/ml, Mouse, Rat
ELISA, 0.1-0.5 μg/ml, - |
Manufacturer - Gene Name |
SLC47A1 |
Gene Full Name |
RAB11B, member RAS oncogene family |
Background |
Multidrug and toxin extrusion protein 1 (MATE1), also known as solute carrier family 47 member 1, is a protein that in humans is encoded by the SLC47A1 gene. This gene is located within the Smith-Magenis syndrome region on chromosome 17. It encodes a protein of unknown function. |
Immunogen |
E.coli-derived human MATE-1/SLC47A1 recombinant protein (Position: M1-D508). |
Contents |
Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4. |
Purification |
Immunogen affinity purified. |
Reconstitution |
Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml. |
Concentration |
Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml. |
Manufacturer - Research Category |
Angiogenesis, Cancer, Cardiovascular, Growth Factors, Growth Factors/Hormones, Invasion/Microenvironment, Neurogenesis, Neurology Process, Neuroscience, Signal Transduction |
Protein Function |
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors ly responsible for vesicle formation, movement, tethering and fusion. That Rab plays a role in endocytic recycling, regulating apical recycling of several transmembrane proteins including cystic fibrosis transmembrane conductance regulator/CFTR, epithelial sodium channel/ENaC, potassium voltage-gated channel, and voltage-dependent L-type calcium channel. May also regulate constitutive and regulated secretion, like insulin granule exocytosis. Required for melanosome transport and release from melanocytes. Also regulates V-ATPase intracellular transport in response to extracellular acidosis. |
Subcellular Localization |
Recycling endosome membrane, Lipid-anchor, Synaptic vesicle membrane, Phagosome membrane. |
Description |
Boster Bio Anti-MATE-1/SLC47A1 Antibody Picoband® catalog # A04529-2. Tested in ELISA, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance. |
Tissue Specificity |
Expressed in all tissues except liver. Highest levels found in heart, skeletal muscle and pancreas. |
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