Anti-LRIG1 Antibody Picoband®

ArtNr	BOS-A04613-1-Cy3
Hersteller	Boster
Menge	100 ug
Quantity options	100 ug/vial 10 ug 100 ug 100 ug 100 ug 100 ug 100 ug 100 ug 100 ug 100 ug 100 ug 100 ug
Kategorie	Neuroscience Neural Signaling Antibodies Immunohistochemistry Western Blot Primary Antibodies
Typ	Antibody Primary
Format	Lyophilized
Applikationen	WB, IHC
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus), Rat (Rattus norvegicus)
Host	Rabbit
Isotype	IgG
Konjugat/Tag	Cy3
Sensitivity	>5000 cells
Citations	1. Guo, D., Holmlund, C., Henriksson, R., Hedman, H. The LRIG gene family has three vertebrate paralogs widely expressed in human and mouse tissues and a homolog in Ascidiacea. Genomics 84: 157-165, 2004. 2. Jensen, K. B., Watt, F. M. Single-cell expression profiling of human epidermal stem and transit-amplifying cells: Lrig1 is a regulator of stem cell quiescence. Proc. Nat. Acad. Sci. 103: 11958-11963, 2006. 3. Nilsson, J., Vallbo, C., Guo, D., Golovleva, I., Hallberg, B., Henriksson, R., Hedman, H. Cloning, characterization, and expression of human LIG1.Biochem. Biophys. Res. Commun. 284: 1155-1161, 2001.
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	Type I iodothyronine deiodinase,5DI,DIOI,Type 1 DI,Type-I 5'-deiodinase,DIO1,ITDI1,TXDI1
Lieferbar
Manufacturer - Category	Primary Antibodies
Storage Conditions	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
Observed Molecular weight	145 kDa
Clonality	Polyclonal
Application Details	Western blot, 0.1-0.5μg/ml Immunohistochemistry (Paraffin-embedded Section), 0.5-1μg/ml
Gene Name	Lrig1
Gene Full Name	iodothyronine deiodinase 1
Manufacturer - Specificity	No cross reactivity with other proteins.
Background	Leucine-rich repeats and immunoglobulin-like domains protein 1 is a protein that in humans is encoded by the LRIG1 gene. It is mapped to 3p14.1. Leucine-rich repeats and immunoglobulin-like domains protein 1 is a protein that in humans is encoded by the LRIG1 gene. It encodes a transmembrane protein that has been shown to interact with receptor tyrosine kinases of the EGFR-family, MET and RET. This gene encodes a member of the ATP-dependent DNA ligase protein family. The encoded protein functions in DNA replication, recombination, and the base excision repair process. Mutations in this gene that lead to DNA ligase I deficiency result in immunodeficiency and increased sensitivity to DNA-damaging agents. Disruption of this gene may also be associated with a variety of cancers. Alternative splicing results in multiple transcript variants.
Immunogen	A synthetic peptide corresponding to a sequence in the middle region of mouse LRIG1, which shares 90% amino acid (aa) sequence identity with human LRIG1.
Contents	Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na₂HPO₄, 0.05mg NaN₃.
Purification	Immunogen affinity purified.
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.
Manufacturer - Research Category	Cancer, Oncoproteins/Suppressors, Tumor Suppressors
Protein Function	Responsible for the deiodination of T4 (3, 5, 3', 5'-tetraiodothyronine) into T3 (3, 5, 3'-triiodothyronine) and of T3 into T2 (3, 3'-diiodothyronine). Plays a role in providing a source of plasma T3 by deiodination of T4 in peripheral tissues such as liver and kidney.
Subcellular Localization	Endoplasmic reticulum membrane. Single-pass membrane protein.
Description	Boster Bio Anti-LRIG1 Antibody Picoband® catalog # A04613-1. Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Tissue Specificity	Widely expressed in adult (at protein level) and fetal tissues.
Manufacturer - Cross Reactivity	No cross-reactivity with other proteins.

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BOS-A04613-1-Cy3-datasheet.pdf

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