ArtNr |
BOS-A04796-Biotin |
Hersteller |
Boster
|
Menge |
100 ug |
Format |
Lyophilized |
Applikationen |
WB, IHC, ELISA |
Specific against |
Human (Homo sapiens), Mouse (Murine, Mus musculus), Rat (Rattus norvegicus) |
Host |
Rabbit |
Isotype |
IgG |
Konjugat/Tag |
Biotin |
Citations |
1. Bianchi C, et al. Primary cell cultures from human renal cortex and renal-cell carcinoma evidence a differential expression of two spliced isoforms of Annexin A3. Am J Pathol, 2010 Apr. 2. Jung EJ, et al. Decreased annexin A3 expression correlates with tumor progression in papillary thyroid cancer. Proteomics Clin Appl, 2010 May. 3. Yan X, et al. Increased expression of annexin A3 is a mechanism of platinum resistance in ovarian cancer. Cancer Res, 2010 Feb 15. |
Alias |
Annexin A3; 35-alpha calcimedin; Annexin III; Annexin-3; Inositol 1,2-cyclic phosphate 2-phosphohydrolase; Lipocortin III; Placental anticoagulant protein III;PAP-III; ANXA3; ANX3 |
Lieferbar |
|
Manufacturer - Category |
Primary Antibodies |
Manufacturer - Isotype |
Rabbit IgG |
Storage Conditions |
Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles. |
Observed Molecular Weight |
36 kDa |
Clonality |
Polyclonal |
Application Details |
Western blot, 0.1-0.5μg/ml
Immunohistochemistry (Paraffin-embedded Section), 0.5-1μg/ml
ELISA, 0.1-0.5μg/ml |
Manufacturer - Gene Name |
ANXA3 |
Gene Full Name |
annexin A3 |
Manufacturer - Specificity |
No cross reactivity with other proteins. |
Background |
Annexin A3 is a protein that in humans is encoded by the Annexin A3 gene. The Annexin A3 gene contains 13 exons and spans 58 kb of genomic DNA. The Annexin A3 gene is mapped to 4q21. It is abnormally expressed in fetuses of both IVF and ICSI, which may contribute to the increase risk of birth defects in these ART. This gene encodes a member of the annexin family. Members of this calcium-dependent phospholipid-binding protein family play a role in the regulation of cellular growth and in signal transduction pathways. This protein functions in the inhibition of phospholipase A2 and cleavage of inositol 1, 2-cyclic phosphate to form inositol 1-phosphate. This protein may also play a role in anti-coagulation. |
Immunogen |
E.coli-derived human Annexin A3/ANXA3 recombinant protein (Position: D23-D323). |
Contents |
Each vial contains 4 mg Trehalose, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05 mg NaN3. |
Purification |
Immunogen affinity purified. |
Reconstitution |
Add 0.2 ml of distilled water will yield a concentration of 500 ug/ml. |
Concentration |
Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml. |
Manufacturer - Research Category |
Lipid Signaling, Signal Transduction, Signaling Pathway |
Protein Function |
Inhibitor of phospholipase A2, also possesses anti-coagulant properties. Also cleaves the cyclic bond of inositol 1, 2-cyclic phosphate to form inositol 1-phosphate. |
Subcellular Localization |
Cytosol. Extracellular exosome. Plasma membrane. Axon. Cytoplasm. Dendrite. Membrane. Neuronal cell body. Phagocytic vesicle membrane. Specific granule. |
Description |
Boster Bio Anti-Annexin A3/ANXA3 Antibody Picoband® catalog # A04796. Tested in ELISA, IHC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance. |
Tissue Specificity |
Widely expressed. Highly expressed in ovary followed by spleen, thymus, prostate, testes and large intestine. Weakly expressed in small intestine. |
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