Anti-TFIIH p62 GTF2H1 Antibody

Primary Antibodies

62032 MW

WB 1:500-1:2000
IHC 1:100-1:300
ELISA 1:20000
IF 1:50-200

General transcription factor IIH subunit 1

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

1 mg/ml

Component of the general transcription and DNA repair
factor IIH (TFIIH) core complex, which is involved in general and
transcription-coupled nucleotide excision repair (NER) of damaged
DNA and, when complexed to CAK, in RNA transcription by RNA
polymerase II. In NER, TFIIH acts by opening DNA around the lesion
to allow the excision of the damaged oligonucleotide and its
replacement by a new DNA fragment. In transcription, TFIIH has an
essential role in transcription initiation. When the pre-
initiation complex (PIC) has been established, TFIIH is required
for promoter opening and promoter escape. Phosphorylation of the
C-terminal tail (CTD) of the largest subunit of RNA polymerase II
by the kinase module CAK controls the initiation of transcription.

Boster Bio Anti-TFIIH p62 GTF2H1 Antibody catalog # A05408-2. Tested in WB, IHC, IF, ELISA applications. This antibody reacts with Human, Mouse.