Anti-CD103/Itgae Antibody

Rabbit IgG

81 kDa

Immunohistochemistry(Paraffin-embedded Section), 2-5 μg/ml, Mouse, Rat
ELISA, 0.1-0.5 μg/ml, -

ribosome binding protein 1

ITGAE(INTEGRIN, ALPHA-E), also known as CD103, is an integrin protein that in human is encoded by the ITGAE gene. The ITGAE gene is mapped to chromosome 17p13 by inclusion within a BAC contig. ITGAE is expressed widely on intraepithelial lymphocyte(IEL) T cells(both alphabeta T cells and gammadelta T cells) and on some peripheral regulatory T cells(Tregs) which is important for decreasing the immune response and appears to play a crucial role in the prevention of autoimmune diseases. ITGAE shares overall homology with other alpha integrins but has a unique 55-amino acid "extra" region located just N-terminal to the I domain that contains 18 consecutive charged residues and a proteolytic cleavage site.

Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Cancer, DNA/RNA, Epigenetics and Nuclear Signaling, Ribosome, Translation, Tumor Biomarkers

Endoplasmic reticulum membrane, Single-pass type III membrane protein.

Expressed in kidney.