Anti-P2Y14/P2ry14 Antibody Picoband®

Rabbit IgG

40 kDa

Western blot, 0.25-0.5?g/ml, Rat

Flow Cytometry (Fixed), 1-3?g/1x10⁶ cells, Mouse

ELISA, 0.1-0.5?g/ml, -

penta-EF-hand domain containing 1

E.coli-derived mouse P2Y14/P2ry14 recombinant protein (Position: N17-L338).

Immunogen affinity purified.

Adding 0.2 ml of distilled water will yield a concentration of 500 ?g/ml.

Calcium-binding protein that acts as an adapter that bridges unrelated proteins or stabilizes weak protein-protein complexes in response to calcium. Together with PDCD6, acts as calcium-dependent adapter for the BCR (KLHL12) complex, a complex involved in endoplasmic reticulum (ER)-Golgi transport by regulating the size of COPII coats. In response to cytosolic calcium increase, the heterodimer formed with PDCD6 interacts with, and bridges together the BCR (KLHL12) complex and SEC31 (SEC31A or SEC31B), promoting monoubiquitination of SEC31 and subsequent collagen export, which is required for neural crest specification. Its role in the heterodimer formed with PDCD6 is however unclear: some evidences show that PEF1 and PDCD6 work together and promote association between PDCD6 and SEC31 in presence of calcium. Other reports show that PEF1 dissociates from PDCD6 in presence of calcium, and may act as a negative regulator of PDCD6. Also acts as a negative regulator of ER-Golgi transport; possibly by inhibiting interaction between PDCD6 and SEC31.

Boster Bio Anti-P2Y14/P2ry14 Antibody Picoband® catalog # A09607-3. Tested in ELISA, Flow Cytometry, WB applications. This antibody reacts with Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.