Anti-TNF alpha Purified Azide Free Monoclonal Antibody

Store at 2-8°C. Do not freeze.

Monoclonal

TNF

TNF-alpha is a cytokine produced by monocytes, macrophages, neutrophils, NK cells, CD4+ T cells and many transformed cells. It can be expressed as a 17 kDa free molecule, or as a 26 kDa membrane protein. TNF-alpha easily forms stable trimers, but also other multimeric complexes. In the immune system, it is an important regulator, which has cytolytic and cytostatic activity against a range of tumor cells, increases fibroblast proliferation and supports neutrophil chemotaxis and phagocytosis.

Phosphate buffered saline (PBS), pH 7.4, azide-free

1 mg/ml

Cytokine that binds to TNFRSF1A/TNFR1 and
TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can
induce cell death of certain tumor cell lines. It is potent
pyrogen causing fever by direct action or by stimulation of
interleukin-1 secretion and is implicated in the induction of
cachexia, Under certain conditions it can stimulate cell
proliferation and induce cell differentiation. Impairs regulatory
T-cells (Treg) function in individuals with rheumatoid arthritis
via FOXP3 dephosphorylation. Upregulates the expression of protein
phosphatase 1 (PP1), which dephosphorylates the key 'Ser-418'
residue of FOXP3, thereby inactivating FOXP3 and rendering Treg
cells functionally defective (PubMed:23396208). Key mediator of
cell death in the anticancer action of BCG-stimulated neutrophils
in combination with DIABLO/SMAC mimetic in the RT4v6 bladder
cancer cell line (PubMed:22517918).

Boster Bio Anti-TNF alpha Purified Azide Free Monoclonal Antibody (Catalog# M00002-1). Tested in WB, ELISA, Functional Assay application(s). This antibody reacts with Human.