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Anti-SAMHD1 Antibody PicobandÂ® (monoclonal, 10H8)

Anti-SAMHD1 Antibody PicobandÂ® (monoclonal, 10H8)

ArtNr	BOS-M00592-3-FITC
Hersteller	Boster
Menge	100 ug
Format	Lyophilized
Applikationen	WB, FC, IF, IHC, ICC
Clon	10H8
Specific against	Human (Homo sapiens)
Host	Mouse
Isotype	IgG2b
Konjugat/Tag	FITC
Sensitivity	>5000 cells
Citations	1. Behrendt, R., Schumann, T., Gerbaulet, A., Nguyen, L. A., Schubert, N., Alexopoulos, D., Berka, U., Lienenklaus, S., Peschke, K., Gibbert, K., Wittmann, S., Lindemann, D., Weiss, S., Dahl, A., Naumann, R., Dittmer, U., Kim, B., Mueller, W., Gramberg, T., Roers, A. Mouse SAMHD1 has antiretroviral activity and suppresses a spontaneous cell-intrinsic antiviral response. Cell Rep. 4: 689-696, 2013. 2. Coquel, F., Silva, M.-J., Techer, H., Zadorozhny, K., Sharma, S., Nieminuszczy, J., Mettling, C., Dardillac, E., Barthe, A., Schmitz, A.-L., Promonet, A., Cribier, A., and 9 others. SAMHD1 acts at stalled replication forks to prevent interferon induction. Nature 557: 57-61, 2018. 3. Crow, Y. J., Chase, D. S., Lowenstein Schmidt, J., Szynkiewicz, M., Forte, G. M. A., Gornall, H. L., Oojageer, A., Anderson, B., Pizzino, A., Helman, G., Abdel-Hamid, M. S., Abdel-Salam, G. M., and 124 others. Characterization of human disease phenotypes associated with mutations in TREX1, RNASEH2A, RNASEH2B, RNASEH2C, SAMHD1, ADAR, and IFIH1. Am. J. Med. Genet. 167A: 296-312, 2015.
Alias	RNA-binding protein EWS; EWS oncogene; Ewing sarcoma breakpoint region 1 protein; EWSR1; EWS
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Manufacturer - Category	Primary Antibodies
Manufacturer - Isotype	Mouse IgG2b
Storage Conditions	Store at -20Â°C for one year from date of receipt. After reconstitution, at 4Â°C for one month. It can also be aliquotted and stored frozen at -20Â°C for six months. Avoid repeated freeze-thaw cycles.
Observed Molecular Weight	72 kDa
Clonality	Monoclonal
Application Details	Western blot, 0.25-0.5Î¼g/ml, Human Immunohistochemistry (Paraffin-embedded Section), 2-5Î¼g/ml, Human Immunocytochemistry/Immunofluorescence, 5Î¼g/ml, Human Flow Cytometry (Fixed), 1-3Î¼g/1x10⁶ cells, Human
Manufacturer - Gene Name	SAMHD1
Gene Full Name	EWS RNA-binding protein 1
Background	SAM domain and HD domain-containing protein 1 is a protein that in humans is encoded by the SAMHD1 gene. This gene may play a role in regulation of the innate immune response. The encoded protein is upregulated in response to viral infection and may be involved in mediation of tumor necrosis factor-alpha proinflammatory responses. Mutations in this gene have been associated with Aicardi-Goutieres syndrome.
Immunogen	E.coli-derived human SAMHD1 recombinant protein (Position: E37-M626).
Contents	Each vial contains 4 mg Trehalose, 0.9mg NaCl and 0.2mg Na2HPO4.
Purification	Immunogen affinity purified.
Reconstitution	Add 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 Î¼g/ml.
Manufacturer - Research Category	Cancer Susceptibility, Cell Type Markers, Chromatin Binding Proteins, DNA/RNA Binding, Epigenetics and Nuclear Signaling, Proto-Oncogenes, Tags & Cell Markers, Transcription, Transcription Factors, Tumor Associated
Protein Function	Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.
Subcellular Localization	Nucleus
Description	Boster Bio Anti-SAMHD1 Antibody Picoband® (monoclonal, 10H8) catalog # M00592-3. Tested in Flow Cytometry, IF, IHC, ICC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Tissue Specificity	Ubiquitous.

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Menge: 100 ug

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Lieferung vsl. bis 12.06.2025

Express-Lieferung: 3 Tage sparen

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