Anti-ATS5 ADAMTS5 Antibody

Primary Antibodies

101718 MW

WB 1:500-2000
ELISA 1:5000-20000

A disintegrin and metalloproteinase with thrombospondin motifs 5

Liquid form in PBS containing 50% glycerol, and 0.02% sodium azide.

1 mg/ml

Metalloproteinase that plays an important role in
connective tissue organization, development, inflammation,
arthritis, and cell migration. ADAMTS5 is an extracellular matrix
(ECM) degrading enzyme that show proteolytic activity toward the
hyalectan group of chondroitin sulfate proteoglycans (CSPGs)
including aggrecan, versican, brevican and neurocan
(PubMed:16133547, PubMed:18992360). Cleavage within the hyalectans
occurs at Glu-Xaa recognition motifs. Plays a role in embryonic
development, including limb and cardiac morphogenesis, and
skeletal muscle development through its versican remodeling
properties. Participates in development of brown adipose tissue
and browning of white adipose tissue. Plays an important role for
T-lymphocyte migration from draining lymph nodes following viral
infection.

Boster Bio Anti-ATS5 ADAMTS5 Antibody catalog # A02802. Tested in ELISA, WB applications. This antibody reacts with Human, Mouse.

Expressed at low level in placenta primarily
but also detected in heart and brain, cervix, uterus, bladder,
esophagus, rib cartilage, chondroblastoma, fibrous tissue and a
joint capsule from an arthritic patient.