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Anti-KCNN4 Antibody Picoband® Europäischer Partner

ArtNr BOS-PA1047-1
Hersteller Boster
Menge 100 ug/vial
Kategorie
Typ Antibody Polyclonal
Format Lyophilized
Applikationen WB
Specific against Human (Homo sapiens), Mouse (Murine, Mus musculus), Rat (Rattus norvegicus)
Host Rabbit
Isotype IgG
Sensitivity <10pg/ml
Citations 1. Joiner WJ, Wang LY, Tang MD, Kaczmarek LK. Joiner,W.J., Wang,L.Y., Tang,M.D. and Kaczmarek,L.K. hSK4, a member of a novel subfamily of calcium-activated potassium channels. Proc. Natl. Acad. Sci. U.S.A.1997; 94 (20), 11013-11018.
2. Hoffman JF, Joiner W, Nehrke K, Potapova O, Foye K, Wickrema A. The hSK4 (KCNN4) isoform is the Ca2+-activated K+ channel (Gardos channel) in human red blood cells. Proc. Natl. Acad. Sci. U.S.A.2003; 100 (12), 7366-7371.
3. Jones HM, Hamilton KL, Papworth GD, Syme CA, Watkins SC, Bradbury NA, Devor DC. Role of the NH2 terminus in the assembly and trafficking of the intermediate conductance Ca2+-activated K+ channel hIK1. J. Biol. Chem.2004; 279 (15), 15531-15540.
ECLASS 10.1 32160702
ECLASS 11.0 32160702
UNSPSC 12352203
Alias Intermediate conductance calcium-activated potassium channel protein 4;SK4;SKCa 4;SKCa4;IKCa1;IK1;KCa3.1;KCa4;Putative Gardos channel;KCNN4;IK1, IKCA1, KCA4, SK4;
Similar products subfamily N, member 4 antibody, hIKCa1 antibody, hKCa4 antibody, hSK4 antibody, IK1 antibody, IKCa1 antibody, Intermediate conductance calcium activated potassium channel protein 4 antibody, Intermediate conductance calcium-activated potassium channel protein 4 antibody, KCa3.1 antibody, KCa4 antibody, KCNN 4 antibody, Kcnn4 antibody, KCNN4_HUMAN antibody, Potassium intermediate/small conductance calcium activated channel, Putative Gardos channel antibody, SK4 antibody, SKCa 4 antibody, SKCa4 antibody
Lieferbar
Specificity No cross reactivity with other proteins.
Manufacturer - Category
Primary Antibodies
Manufacturer - Isotype
Rabbit IgG
Storage Conditions
Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
Observed Molecular Weight
48 kDa
Calculated Molecular weight
47696 MW
Clonality
Polyclonal
Application Details
Western blot, 0.1-0.5?g/ml, Human, Mouse, Rat
Manufacturer - Gene Name
KCNN4
Gene Full Name
Intermediate conductance calcium-activated potassium channel protein 4
Manufacturer - Specificity
No cross reactivity with other proteins.
Background
Intermediate conductance calcium-activated potassium channel protein 1 (KCNN4, Kca3.1) is part of a potentially heterotetrameric voltage-independent potassium channel that is activated by intracellular calcium. Activation is followed by membrane hyperpolarization, which promotes calcium influx. KCNN4 may be part of the predominant calcium-activated potassium channel in T-lymphocytes. This gene is similar to other KCNN family potassium channel genes, but it differs enough to possibly be considered as part of a new subfamily.
Immunogen
A synthetic peptide corresponding to a sequence at the N-terminus of human KCNN4, different from the related mouse and rat sequences by two amino acids.
Contents
Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.
Purification
Immunogen affinity purified.
Reconstitution
Add 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Concentration
Adding 0.2 ml of distilled water will yield a concentration of 500 ?g/ml.
Manufacturer - Research Category
Cell Biology, Neuroscience, Neurotransmission, Potassium Channels, Receptors / Channels
Protein Name
Intermediate conductance calcium-activated potassium channel protein 4
Protein Function
Forms a voltage-independent potassium channel that is activated by intracellular calcium. Activation is followed by membrane hyperpolarization which promotes calcium influx. Required for maximal calcium influx and proliferation during the reactivation of naive T-cells. The channel is blocked by clotrimazole and charybdotoxin but is insensitive to apamin.
Subcellular Localization
Membrane; Multi-pass membrane protein.
Description
Boster Bio Anti-KCNN4 Antibody catalog # PA1047-1. Tested in WB applications. This antibody reacts with Human, Mouse, Rat.
Tissue Specificity
Widely expressed in non-excitable tissues.
Sequence Similarities
Belongs to the integrin alpha chain family.

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

Menge: 100 ug/vial
Lieferbar: In stock
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