Anti-Cystathionase/CTH Antibody Picoband®

Primary Antibodies

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

44508 MW

Western blot, 0.1-0.5?g/ml, Human, Mouse, Rat

Immunocytochemistry/Immunofluorescence, 5 ?g/ml, Human

Flow Cytometry (Fixed), 1-3 ?g/1x10⁶ cells, Human

Cystathionine gamma-lyase

Cystathionine gamma-lyase (or cystathionase) is an enzyme which breaks down cystathionine into cysteine and alpha-ketobutyrate. The International Radiation Hybrid Mapping Consortium mapped the CTH gene to chromosome 1. The CTH gene had earlier been assigned to chromosome 16 by study of somatic cell hybrids. It is demonstrated that hydrogen sulfide (H2S) is physiologically generated by CTH.

Each vial contains 4 mg Trehalose, 0.9mg NaCl and 0.2mg Na2HPO4.

Add 0.2 ml of distilled water will yield a concentration of 500 ug/ml.

Cancer, Cardiovascular, Collagen, Cytoskeleton/ECM, ECM Proteins, Extracellular Matrix, Growth Factors/Hormones, Invasion/Microenvironment, Signal Transduction, Tumor Biomarkers, Tumor Immunology, Tumor-Associated Antigens, Vasculature

Catalyzes the last step in the trans-sulfuration pathway from methionine to cysteine. Has broad substrate specificity. Converts cystathionine to cysteine, ammonia and 2-oxobutanoate. Converts two cysteine molecules to lanthionine and hydrogen sulfide. Can also accept homocysteine as substrate. Specificity depends on the levels of the endogenous substrates. Generates the endogenous signaling molecule hydrogen sulfide (H2S), and so contributes to the regulation of blood pressure. Acts as a cysteine-protein sulfhydrase by mediating sulfhydration of target proteins: sulfhydration consists of converting -SH groups into -SSH on specific cysteine residues of target proteins such as GAPDH, PTPN1 and NF-kappa-B subunit RELA, thereby regulating their function.

Boster Bio Anti-Cystathionase/CTH Antibody catalog # PA1556. Tested in Flow Cytometry, IF, ICC, WB applications. This antibody reacts with Human, Mouse, Rat.