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Anti-Laminin 2 alpha/LAMA2 Antibody Picoband® Europäischer Partner

ArtNr BOS-PA2160
Hersteller Boster
Menge 100 ug/vial
Kategorie
Typ Antibody Polyclonal
Format Lyophilized
Applikationen WB
Specific against Human (Homo sapiens), Mouse (Murine, Mus musculus), Rat (Rattus norvegicus)
Host Rabbit
Isotype IgG
Sensitivity <10pg/ml
Citations 1. Coral-Vazquez, R. M., Rosas-Vargas, H., Meza-Espinosa, P., Mendoza, I., Huicochea, J. C., Ramon, G., Salamanca, F. Severe congenital muscular dystrophy in a Mexican family with a new nonsense mutation (R2578X) in the laminin alpha-2 gene. J. Hum. Genet. 48: 91-95, 2003.
2. Millay, D. P., Sargent, M. A., Osinska, H., Baines, C. P., Barton, E. R., Vuagniaux, G., Sweeney, H. L., Robbins, J., Molkentin, J. D. Genetic and pharmacologic inhibition of mitochondrial-dependent necrosis attenuates muscular dystrophy. Nature Med. 14: 442-447, 2008.
ECLASS 10.1 32160702
ECLASS 11.0 32160702
UNSPSC 12352203
Alias Laminin subunit alpha-2;Laminin M chain;Laminin-12 subunit alpha;Laminin-2 subunit alpha;Laminin-4 subunit alpha;Merosin heavy chain;LAMA2;LAMM;
Similar products LAMA 2 antibody, LAMA2 antibody, LAMA2_HUMAN antibody, Laminin alpha 2(merosin congenital muscular dystrophy) antibody, Laminin alpha 2 antibody, Laminin alpha 2 chain antibody, Laminin alpha 2 subunit antibody, Laminin M antibody, Laminin M chain antibody, Laminin subunit alpha-2 antibody, Laminin-12 subunit alpha antibody, Laminin-2 subunit alpha antibody, Laminin-4 subunit alpha antibody, LAMM antibody, Merosin heavy chain antibody
Lieferbar
Manufacturer - Category
Primary Antibodies
Manufacturer - Isotype
Rabbit IgG
Storage Conditions
Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
Observed Molecular Weight
14 kDa
Calculated Molecular weight
343905 MW
Clonality
Polyclonal
Application Details
Western blot, 0.1-0.5?g/ml, Human, Mouse, Rat
Manufacturer - Gene Name
LAMA2
Gene Full Name
Laminin subunit alpha-2
Manufacturer - Specificity
No cross reactivity with other proteins.
Background
Laminin, alpha-2, also known as LAMA2, is a protein that in humans is encoded by the LAMA2 gene. This gene is mapped to 6q22.33. Laminin, an extracellular protein, is a major component of the basement membrane. It is though to mediate the attachment, migration, and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. It is composed of three subunits, alpha, beta, and gamma, which are bound to each other by disulfide bonds into a cross-shaped molecule. This gene encodes the alpha 2 chain, which constitutes one of the subunits of laminin 2 (merosin) and laminin 4 (s-merosin). Mutations in this gene have been identified as the cause of congenital merosin-deficient muscular dystrophy. Two transcript variants encoding different proteins have been found for this gene.
Immunogen
A synthetic peptide corresponding to a sequence at the N-terminus of human Laminin 2 alpha, identical to the related mouse sequence, and different from the related rat sequence by one amino acid.
Contents
Each vial contains 5 mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg NaN3.
Purification
Immunogen affinity purified.
Reconstitution
Add 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Concentration
Adding 0.2 ml of distilled water will yield a concentration of 500 ?g/ml.
Manufacturer - Research Category
Cell Adhesion Proteins, Cytoskeleton/ECM, ECM Proteins, Intermediate Filaments, Neuroscience, Signal Transduction
Protein Name
Laminin subunit alpha-2
Protein Function
Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.
Subcellular Localization
Secreted, extracellular space, extracellular matrix, basement membrane. Major component.
Description
Boster Bio Anti-Laminin 2 alpha/LAMA2 Antibody catalog # PA2160. Tested in WB applications. This antibody reacts with Human, Mouse, Rat.
Tissue Specificity
Placenta, striated muscle, peripheral nerve, cardiac muscle, pancreas, lung, spleen, kidney, adrenal gland, skin, testis, meninges, choroid plexus, and some other regions of the brain; not in liver, thymus and bone.
Sequence Similarities
Contains 17 laminin EGF-like domains.

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

Menge: 100 ug/vial
Lieferbar: In stock
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