Anti-Kv1.6/KCNA6 Antibody

58729 MW

Insulin receptor substrate 1

A synthetic peptide corresponding to a sequence at the C-terminus of human Kv1.6(515-529aa TPHRAYAEKRMLTEV), identical to the related mouse and rat sequences.

Immunogen affinity purified.

Add 0.2 ml of distilled water will yield a concentration of 500ug/ml.

Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes. Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient (PubMed:2347305, PubMed:14575698). The channel alternates between opened and closed conformations in response to the voltage difference across the membrane (PubMed:2347305, PubMed:14575698). Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNA1, KCNA2, KCNA4, KCNA6, and possibly other family members as well; channel properties depend on the type of alpha subunits that are part of the channel (By similarity). Channel properties are modulated by cytoplasmic beta subunits that regulate the subcellular location of the alpha subunits and promote rapid inactivation (By similarity). Homotetrameric channels display rapid activation and slow inactivation (PubMed:2347305).