|
Hersteller |
Boster
|
|
Kategorie |
|
|
Typ |
Antibody Primary |
|
Specific against |
other |
|
Isotype |
IgG |
|
Format |
Liquid |
|
Applikationen |
FC |
|
Menge |
100ug/vial |
|
Host |
Rabbit |
|
ArtNr |
BOS-A01490-Dyl488 |
|
eClass 6.1 |
32160702 |
|
eClass 9.0 |
32160702 |
|
Lieferbar |
 |
| Clonality |
Polyclonal |
| Description short |
Rabbit IgG Polyclonal Anti-Human Neurexin 1 Antibody DyLight 488 Conjugated, Flow Validated. |
| Specificity |
No cross reactivity with other proteins. |
| Reactivity |
Reacts with: human |
| Application details |
Flow Cytometry|1-3ug/1x106 cells |
| Notes |
Other applications have not been tested.
Optimal dilutions should be determined by end users. |
| Immunogen |
E. coli-derived human Neurexin 1 recombinant protein (Position: D141-E294). |
| Contents |
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3. |
| Purification |
Immunogen affinity purified. |
| Storage |
At 2-8C for one year. Protect from light. Do not freeze. |
| Background |
Neurexin-1-alpha is a protein that in humans is encoded by the NRXN1 gene. This gene encodes a single-pass type I membrane protein that belongs to the neurexin family. Neurexins are cell-surface receptors that bind neuroligins to form Ca(2+)-dependent neurexin/neuroligin complexes at synapses in the central nervous system. This complex is required for efficient neurotransmission and is involved in the formation of synaptic contacts. Three members of this gene family have been studied in detail and are estimated to generate over 3, 000 variants through the use of two alternative promoters (alpha and beta) and extensive alternative splicing in each family member. Recently, a third promoter (gamma) was identified for this gene in the 3' region. Mutations in this gene are associated with Pitt-Hopkins-like syndrome-2 and may contribute to susceptibility to schizophrenia. |
| Reference |
1. Comoletti, Davide; Flynn Robyn; Jennings Lori L; Chubykin Alexander; Matsumura Takehito; Hasegawa Hana; Südhof Thomas C; Taylor Palmer (Dec 2003). "Characterization of the interaction of a recombinant soluble neuroligin-1 with neurexin-1beta". J. Biol. Chem. United States. 278 (50): 50497–50505.
2. Nguyen T, Südhof TC (1997). "Binding properties of neuroligin 1 and neurexin 1beta reveal function as heterophilic cell adhesion molecules". J. Biol. Chem. 272 (41): 26032–26039. |
| Gene Name |
NRXN1 |
| Protein Name |
Neurexin-1-beta |
| Gene Full Name |
neurexin 1 |
| Synonyms |
Neurexin-1-beta; Neurexin I-beta; NRXN1 |
| Uniprot ID |
P58400 |
| Entrez GeneID |
9378 |
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