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Anti-Human Neurexin 1 DyLight® 488 conjugated NRXN1 Antibody Europäischer Partner

ArtNr BOS-A01490-Dyl488
Hersteller Boster
Menge 100 ug/vial
Kategorie
Typ Antibody Primary
Format Liquid
Applikationen FC
Specific against Human (Homo sapiens)
Host Rabbit
Isotype IgG
Konjugat/Tag DyLight 488
Citations 1. Comoletti, Davide; Flynn Robyn; Jennings Lori L; Chubykin Alexander; Matsumura Takehito; Hasegawa Hana; Südhof Thomas C; Taylor Palmer (Dec 2003). "Characterization of the interaction of a recombinant soluble neuroligin-1 with neurexin-1beta". J. Biol. Chem. United States. 278 (50): 50497–50505.
2. Nguyen T, Südhof TC (1997). "Binding properties of neuroligin 1 and neurexin 1beta reveal function as heterophilic cell adhesion molecules". J. Biol. Chem. 272 (41): 26032–26039.
ECLASS 10.1 32160702
ECLASS 11.0 32160702
UNSPSC 12352203
Alias Neurexin-1-beta; Neurexin I-beta; NRXN1
Lieferbar
Specificity No cross reactivity with other proteins.
Manufacturer - Category
Primary Antibodies
Manufacturer - Isotype
Rabbit IgG
Storage Conditions
At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Observed Molecular Weight
39 kDa
Calculated Molecular weight
25722 MW
Clonality
Polyclonal
Application Details
Flow Cytometry (Fixed), 1-3?g/1x106 cells
Manufacturer - Gene Name
NRXN1
Gene Full Name
neurexin 1
Manufacturer - Specificity
No cross reactivity with other proteins.
Background
Neurexin-1-alpha is a protein that in humans is encoded by the NRXN1 gene. This gene encodes a single-pass type I membrane protein that belongs to the neurexin family. Neurexins are cell-surface receptors that bind neuroligins to form Ca (2+)-dependent neurexin/neuroligin complexes at synapses in the central nervous system. This complex is required for efficient neurotransmission and is involved in the formation of synaptic contacts. Three members of this gene family have been studied in detail and are estimated to generate over 3, 000 variants through the use of two alternative promoters (alpha and beta) and extensive alternative splicing in each family member. Recently, a third promoter (gamma) was identified for this gene in the 3' region. Mutations in this gene are associated with Pitt-Hopkins-like syndrome-2 and may contribute to susceptibility to schizophrenia.
Immunogen
E. coli-derived human Neurexin 1 recombinant protein (Position: D141-E294).
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
Purification
Immunogen affinity purified.
Reconstitution
Add 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Concentration
0.5-1mg/ml, actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.
Manufacturer - Research Category
Adapters, Axonal Guidance Proteins, Cell Adhesion Proteins, Cell Type Marker, Growth and Development, Membrane Proteins, Neurology Process, Neuron Marker, Neuroscience, Signal Transduction, Synapse Marker, Transmembrane
Protein Name
Glutathione S-transferase A1
Protein Function
Neuronal cell surface protein that may be involved in cell recognition and cell adhesion by forming intracellular junctions through binding to neuroligins. May play a role in formation or maintenance of synaptic junctions. May mediate intracellular signaling. May play a role in angiogenesis (By similarity).
Subcellular Localization
Cell membrane; Localized on the pre- synaptic membrane.
Description
Boster Bio Anti-Human Neurexin 1 DyLight® 488 conjugated NRXN1 Antibody catalog # A01490-Dyl488. Tested in Flow Cytometry applications. This antibody reacts with Human.
Tissue Specificity
Liver.

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

Menge: 100 ug/vial
Lieferbar: In stock
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