ArtNr |
BOS-A01490-Dyl488 |
Hersteller |
Boster
|
Menge |
100 ug/vial |
Kategorie |
|
Typ |
Antibody Primary |
Format |
Liquid |
Applikationen |
FC |
Specific against |
Human (Homo sapiens) |
Host |
Rabbit |
Isotype |
IgG |
Konjugat/Tag |
DyLight 488 |
Citations |
1. Comoletti, Davide; Flynn Robyn; Jennings Lori L; Chubykin Alexander; Matsumura Takehito; Hasegawa Hana; Südhof Thomas C; Taylor Palmer (Dec 2003). "Characterization of the interaction of a recombinant soluble neuroligin-1 with neurexin-1beta". J. Biol. Chem. United States. 278 (50): 50497–50505. 2. Nguyen T, Südhof TC (1997). "Binding properties of neuroligin 1 and neurexin 1beta reveal function as heterophilic cell adhesion molecules". J. Biol. Chem. 272 (41): 26032–26039. |
ECLASS 10.1 |
32160702 |
ECLASS 11.0 |
32160702 |
UNSPSC |
12352203 |
Alias |
Neurexin-1-beta; Neurexin I-beta; NRXN1 |
Lieferbar |
|
Specificity |
No cross reactivity with other proteins. |
Manufacturer - Category |
Primary Antibodies |
Manufacturer - Isotype |
Rabbit IgG |
Storage Conditions |
At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light. |
Observed Molecular Weight |
39 kDa |
Calculated Molecular weight |
25722 MW |
Clonality |
Polyclonal |
Application Details |
Flow Cytometry (Fixed), 1-3?g/1x106 cells |
Manufacturer - Gene Name |
NRXN1 |
Gene Full Name |
neurexin 1 |
Manufacturer - Specificity |
No cross reactivity with other proteins. |
Background |
Neurexin-1-alpha is a protein that in humans is encoded by the NRXN1 gene. This gene encodes a single-pass type I membrane protein that belongs to the neurexin family. Neurexins are cell-surface receptors that bind neuroligins to form Ca (2+)-dependent neurexin/neuroligin complexes at synapses in the central nervous system. This complex is required for efficient neurotransmission and is involved in the formation of synaptic contacts. Three members of this gene family have been studied in detail and are estimated to generate over 3, 000 variants through the use of two alternative promoters (alpha and beta) and extensive alternative splicing in each family member. Recently, a third promoter (gamma) was identified for this gene in the 3' region. Mutations in this gene are associated with Pitt-Hopkins-like syndrome-2 and may contribute to susceptibility to schizophrenia. |
Immunogen |
E. coli-derived human Neurexin 1 recombinant protein (Position: D141-E294). |
Contents |
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3. |
Purification |
Immunogen affinity purified. |
Reconstitution |
Add 0.2 ml of distilled water will yield a concentration of 500 ug/ml. |
Concentration |
0.5-1mg/ml, actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure. |
Manufacturer - Research Category |
Adapters, Axonal Guidance Proteins, Cell Adhesion Proteins, Cell Type Marker, Growth and Development, Membrane Proteins, Neurology Process, Neuron Marker, Neuroscience, Signal Transduction, Synapse Marker, Transmembrane |
Protein Name |
Glutathione S-transferase A1 |
Protein Function |
Neuronal cell surface protein that may be involved in cell recognition and cell adhesion by forming intracellular junctions through binding to neuroligins. May play a role in formation or maintenance of synaptic junctions. May mediate intracellular signaling. May play a role in angiogenesis (By similarity). |
Subcellular Localization |
Cell membrane; Localized on the pre- synaptic membrane. |
Description |
Boster Bio Anti-Human Neurexin 1 DyLight® 488 conjugated NRXN1 Antibody catalog # A01490-Dyl488. Tested in Flow Cytometry applications. This antibody reacts with Human. |
Tissue Specificity |
Liver. |
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