|
Hersteller |
Boster
|
|
Kategorie |
|
|
Typ |
Antibody |
|
Specific against |
other |
|
Applikationen |
WB, IP, IHC |
|
Menge |
50 ul |
|
Host |
Rabbit |
|
ArtNr |
BOS-A01700 |
|
eClass 6.1 |
32160702 |
|
eClass 9.0 |
32160702 |
|
Lieferbar |
 |
| Gene name |
BIRC2 |
| Clonality |
Polyclonal |
| Conjugate |
No |
| Contents |
50 ul sera |
| Description |
Polyclonal antibody for CIAP1/BIRC2 detection. Host: Rabbit.Size: 100 ug. Tested applications: IP. Reactive species: Canine. CIAP1/BIRC2 information: Molecular Weight: 69900 MW; Subcellular Localization: Cytoplasm. Nucleus. Agents that induce either the extrinsic or intrinsic apoptotic pathways promote its redistribution from the nuclear compartment to the cytoplasmic compartment. Associated with the midbody in telophase cells, and found diffusely in the nucleus of interphase cells; Tissue Specificity: Present in many fetal and adult tissues. Mainly expressed in adult skeletal muscle, thymus, testis, ovary, and pancreas, low or absent in brain and peripheral blood leukocytes. |
| Uniprot ID |
Q13490 |
| Immunogen |
Full-length recombinant protein of human cAIP1 |
| Storage |
Store the antibody at 4° C, stable for 6 months. For long-term storage, store at -20° C. Avoid repeated freeze and thaw cycles. |
| Application details |
WB, 1:1000-1:2000
IHC (paraffin), 1:1000-1:5000
IHC (frozen), Users should optimize
IP, 1:50-1:200
|
| Reactivity |
Canine, Human, Mouse, Rat |
| Research category |
|cell biology|apoptosis|intracellular|survivin / iaps|
cancer|invasion/microenvironment|caspases|death receptors & ligands|cancer metabolism|response to hypoxia|
metabolism|pathways and processes|metabolism processes|types of disease|cell death|apoptotic markers|receptors|necroptosis |
| Synonyms |
Baculoviral IAP repeat-containing protein 2, 6.3.2.-, Cellular inhibitor of apoptosis 1, C-IAP1 , IAP homolog B, Inhibitor of apoptosis protein 2, hIAP-2, hIAP2, RING finger protein 48, TNFR2-TRAF-signaling complex protein 2, BIRC2, API1, MIHB, RNF48, |
| Molecular weight |
69900 MW |
| Protein function |
Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, mitogenic kinase signaling, and cell proliferation, as well as cell invasion and metastasis. Acts as an E3 ubiquitin- protein ligase regulating NF-kappa-B signaling and regulates both canonical and non-canonical NF-kappa-B signaling by acting in opposite directions: acts as a positive regulator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling. The target proteins for its E3 ubiquitin- protein ligase activity include: RIPK1, RIPK2, RIPK3, RIPK4, CASP3, CASP7, CASP8, TRAF2, DIABLO/SMAC, MAP3K14/NIK, MAP3K5/ASK1, IKBKG/NEMO, IKBKE and MXD1/MAD1. Can also function as an E3 ubiquitin-protein ligase of the NEDD8 conjugation pathway, targeting effector caspases for neddylation and inactivation. Acts as an important regulator of innate immune signaling via regulation of Toll-like receptors (TLRs), Nodlike receptors (NLRs) and RIG-I like receptors (RLRs), collectively referred to as pattern recognition receptors (PRRs). Protects cells from spontaneous formation of the ripoptosome, a large multi-protein complex that has the capability to kill cancer cells in a caspase- dependent and caspase-independent manner. Suppresses ripoptosome formation by ubiquitinating RIPK1 and CASP8. Can stimulate the transcriptional activity of E2F1. Plays a role in the modulation of the cell cycle. . |
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