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Anti-cIAP-1/HIAP-2 BIRC2 Antibody Europäischer Partner

ArtNr BOS-A01700
Hersteller Boster
Menge 50 ul
Kategorie
Typ Antibody
Format Liquid
Applikationen WB, IP, IHC
Specific against Human (Homo sapiens), Mouse (Murine, Mus musculus), Rat (Rattus norvegicus), Dog (Canine, Canis lupus familiaris)
Host Rabbit
Isotype IgG
ECLASS 10.1 32160702
ECLASS 11.0 32160702
UNSPSC 12352203
Alias Baculoviral IAP repeat-containing protein 2;6.3.2.-;Cellular inhibitor of apoptosis 1;C-IAP1;IAP homolog B;Inhibitor of apoptosis protein 2;hIAP-2;hIAP2;RING finger protein 48;TNFR2-TRAF-signaling complex protein 2;BIRC2;API1, MIHB, RNF48;
Lieferbar
Specificity Canine,Gerbil,Human,Mouse,Rat
Manufacturer - Category
Primary Antibodies
Manufacturer - Isotype
Rabbit IgG
Storage Conditions
Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.
Observed Molecular Weight
69900 MW
Clonality
Polyclonal
Application Details
WB: 1:1000-1:2000
IHC (paraffin): 1:1000-1:5000
IHC (frozen): Users should optimize
IP: 1:50-1:200
Manufacturer - Gene Name
BIRC2
Gene Full Name
Baculoviral IAP repeat-containing protein 2
Immunogen
Full-length recombinant protein of human cAIP1
Contents
50 μ l sera
Concentration
0.5-1mg/ml, actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.
Manufacturer - Research Category
Apoptosis, Apoptotic Markers, Cancer, Cancer Metabolism, Cell Biology, Cell Death, Intracellular, Invasion/Microenvironment, Metabolism, Metabolism Processes, Pathways and Processes, Receptors, Response To Hypoxia
Protein Name
Baculoviral IAP repeat-containing protein 2
Protein Function
Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, mitogenic kinase signaling, and cell proliferation, as well as cell invasion and metastasis. Acts as an E3 ubiquitin- protein ligase regulating NF-kappa-B signaling and regulates both canonical and non-canonical NF-kappa-B signaling by acting in opposite directions: acts as a positive regulator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling. The target proteins for its E3 ubiquitin- protein ligase activity include: RIPK1, RIPK2, RIPK3, RIPK4, CASP3, CASP7, CASP8, TRAF2, DIABLO/SMAC, MAP3K14/NIK, MAP3K5/ASK1, IKBKG/NEMO, IKBKE and MXD1/MAD1. Can also function as an E3 ubiquitin-protein ligase of the NEDD8 conjugation pathway, targeting effector caspases for neddylation and inactivation. Acts as an important regulator of innate immune signaling via regulation of Toll-like receptors (TLRs), Nodlike receptors (NLRs) and RIG-I like receptors (RLRs), collectively referred to as pattern recognition receptors (PRRs). Protects cells from spontaneous formation of the ripoptosome, a large multi-protein complex that has the capability to kill cancer cells in a caspase- dependent and caspase-independent manner. Suppresses ripoptosome formation by ubiquitinating RIPK1 and CASP8. Can stimulate the transcriptional activity of E2F1. Plays a role in the modulation of the cell cycle.
Subcellular Localization
Cytoplasm. Nucleus. Agents that induce either the extrinsic or intrinsic apoptotic pathways promote its redistribution from the nuclear compartment to the cytoplasmic compartment. Associated with the midbody in telophase cells, and found diffusely in the nucleus of interphase cells.
Short Description
Boster Bio Anti-cIAP-1/HIAP-2 BIRC2 Antibody (Catalog# A01700). Tested in WB, IHC, IP application(s). This antibody reacts with Canine, Gerbil, Human, Mouse, Rat.
Description
Boster Bio Anti-cIAP-1/HIAP-2 BIRC2 Antibody (Catalog# A01700). Tested in WB, IHC, IP application(s). This antibody reacts with Canine, Gerbil, Human, Mouse, Rat.
Tissue Specificity
Present in many fetal and adult tissues. Mainly expressed in adult skeletal muscle, thymus, testis, ovary, and pancreas, low or absent in brain and peripheral blood leukocytes.

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

Menge: 50 ul
Lieferbar: In stock
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