ArtNr |
BOS-A01700 |
Hersteller |
Boster
|
Menge |
50 ul |
Kategorie |
|
Typ |
Antibody |
Format |
Liquid |
Applikationen |
WB, IP, IHC |
Specific against |
Human (Homo sapiens), Mouse (Murine, Mus musculus), Rat (Rattus norvegicus), Dog (Canine, Canis lupus familiaris) |
Host |
Rabbit |
Isotype |
IgG |
ECLASS 10.1 |
32160702 |
ECLASS 11.0 |
32160702 |
UNSPSC |
12352203 |
Alias |
Baculoviral IAP repeat-containing protein 2;6.3.2.-;Cellular inhibitor of apoptosis 1;C-IAP1;IAP homolog B;Inhibitor of apoptosis protein 2;hIAP-2;hIAP2;RING finger protein 48;TNFR2-TRAF-signaling complex protein 2;BIRC2;API1, MIHB, RNF48; |
Lieferbar |
|
Specificity |
Canine,Gerbil,Human,Mouse,Rat |
Manufacturer - Category |
Primary Antibodies |
Manufacturer - Isotype |
Rabbit IgG |
Storage Conditions |
Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles. |
Observed Molecular Weight |
69900 MW |
Clonality |
Polyclonal |
Application Details |
WB: 1:1000-1:2000 IHC (paraffin): 1:1000-1:5000 IHC (frozen): Users should optimize IP: 1:50-1:200 |
Manufacturer - Gene Name |
BIRC2 |
Gene Full Name |
Baculoviral IAP repeat-containing protein 2 |
Immunogen |
Full-length recombinant protein of human cAIP1 |
Contents |
50 μ l sera |
Concentration |
0.5-1mg/ml, actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure. |
Manufacturer - Research Category |
Apoptosis, Apoptotic Markers, Cancer, Cancer Metabolism, Cell Biology, Cell Death, Intracellular, Invasion/Microenvironment, Metabolism, Metabolism Processes, Pathways and Processes, Receptors, Response To Hypoxia |
Protein Name |
Baculoviral IAP repeat-containing protein 2 |
Protein Function |
Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, mitogenic kinase signaling, and cell proliferation, as well as cell invasion and metastasis. Acts as an E3 ubiquitin- protein ligase regulating NF-kappa-B signaling and regulates both canonical and non-canonical NF-kappa-B signaling by acting in opposite directions: acts as a positive regulator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling. The target proteins for its E3 ubiquitin- protein ligase activity include: RIPK1, RIPK2, RIPK3, RIPK4, CASP3, CASP7, CASP8, TRAF2, DIABLO/SMAC, MAP3K14/NIK, MAP3K5/ASK1, IKBKG/NEMO, IKBKE and MXD1/MAD1. Can also function as an E3 ubiquitin-protein ligase of the NEDD8 conjugation pathway, targeting effector caspases for neddylation and inactivation. Acts as an important regulator of innate immune signaling via regulation of Toll-like receptors (TLRs), Nodlike receptors (NLRs) and RIG-I like receptors (RLRs), collectively referred to as pattern recognition receptors (PRRs). Protects cells from spontaneous formation of the ripoptosome, a large multi-protein complex that has the capability to kill cancer cells in a caspase- dependent and caspase-independent manner. Suppresses ripoptosome formation by ubiquitinating RIPK1 and CASP8. Can stimulate the transcriptional activity of E2F1. Plays a role in the modulation of the cell cycle. |
Subcellular Localization |
Cytoplasm. Nucleus. Agents that induce either the extrinsic or intrinsic apoptotic pathways promote its redistribution from the nuclear compartment to the cytoplasmic compartment. Associated with the midbody in telophase cells, and found diffusely in the nucleus of interphase cells. |
Short Description |
Boster Bio Anti-cIAP-1/HIAP-2 BIRC2 Antibody (Catalog# A01700). Tested in WB, IHC, IP application(s). This antibody reacts with Canine, Gerbil, Human, Mouse, Rat. |
Description |
Boster Bio Anti-cIAP-1/HIAP-2 BIRC2 Antibody (Catalog# A01700). Tested in WB, IHC, IP application(s). This antibody reacts with Canine, Gerbil, Human, Mouse, Rat. |
Tissue Specificity |
Present in many fetal and adult tissues. Mainly expressed in adult skeletal muscle, thymus, testis, ovary, and pancreas, low or absent in brain and peripheral blood leukocytes. |
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