Anti-HtrA2/Omi Antibody

Hersteller Boster
Kategorie
Typ Antibody
Specific against other
Applikationen IHC
Menge 100ug/vial
Host Rabbit
ArtNr BOS-A01941-1
eClass 6.1 32160702
eClass 9.0 32160702
Lieferbar
Gene name
HTRA2
Clonality
Polyclonal
Conjugate
No
Contents
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Description
Polyclonal antibody for Omi/HTRA2 detection. Host: Rabbit.Size: 100ug/vial. Tested applications: IHC. Reactive species: Human. Omi/HTRA2 information: Molecular Weight: 48841 MW; Subcellular Localization: Mitochondrion intermembrane space. Mitochondrion membrane ; Single-pass membrane protein . Predominantly present in the intermembrane space. Released into the cytosol following apoptotic stimuli, such as UV treatment, and stimulation of mitochondria with caspase-8 truncated BID/tBID; Tissue Specificity: Isoform 1 is ubiquitous. Isoform 2 is expressed predominantly in the kidney, colon and thyroid.
Uniprot ID
O43464
Immunogen
A peptide derived from human HtrA2. Immunogen sequence location: 181-230
Purification
The antibody was purified from rabbit antiserum by affinity-chromatography using immunogen.
Storage
At -20° C for one year. After reconstitution, at 4° C for one month. It can also be aliquotted and stored frozen at -20° C for a longer time.Avoid repeated freezing and thawing.
Application details
User need to optimize the dilution ratio for this antibody
Reactivity
Human, Mouse, Rat
Research category
|neuroscience|neurology process|neurodegenerative disease|parkinson's disease|parkin / park| cell biology|apoptosis|mitochondrial|other antibodies|oxidative stress| cancer|invasion/microenvironment| metabolism|pathways and processes|mitochondrial metabolism|mitochondrial markers|redox metabolism|metabolism processes|cell death
Synonyms
Serine protease HTRA2, mitochondrial, 3.4.21.108, High temperature requirement protein A2, HtrA2, Omi stress-regulated endoprotease, Serine protease 25, Serine proteinase OMI, HTRA2, OMI, PRSS25,
Molecular weight
48841 MW
Protein function
Serine protease that shows proteolytic activity against a non-specific substrate beta-casein. Promotes or induces cell death either by direct binding to and inhibition of BIRC proteins (also called inhibitor of apoptosis proteins, IAPs), leading to an increase in caspase activity, or by a BIRC inhibition-independent, caspase-independent and serine protease activity-dependent mechanism. Cleaves THAP5 and promotes its degradation during apoptosis. Isoform 2 seems to be proteolytically inactive. .

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Menge: 100ug/vial
Lieferbar: In stock
Listenpreis: 386,89 €
Preis: 386,89 €
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