Anti-SIRT5/Sirtuin 5 Antibody

Store at -80°C for long-term storage. Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -80°C.

Polyclonal

SIRT5

Recombinant human SIRT5

Partially purified from rabbit serum with immunodepletion.

Acetylation, Cancer, Cardiovascular, Chromatin Modifying Enzymes, Epigenetics and Nuclear Signaling, Metabolism

NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins (PubMed:21908771, PubMed:22076378, PubMed:24703693). Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting: acts by mediating desuccinylation and deglutarylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting (PubMed:22076378, PubMed:24703693). Activates SOD1 by mediating its desuccinylation, leading to reduced reactive oxygen species (PubMed:24140062). Modulates ketogenesis through the desuccinylation and activation of HMGCS2 (By similarity). Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo. Can deacetylate cytochrome c (CYCS) and a number of other proteins in vitro such as UOX.

Boster Bio Anti-SIRT5/Sirtuin 5 Antibody (Catalog# A02395). Tested in WB application(s). This antibody reacts with Human, Mouse, Rat, Bovine.

Widely expressed.