Anti-MRF2 ARID5B Antibody

Primary Antibodies

Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.

Polyclonal

ARID5B

A partial length recombinant MRF2 protein (amino acids 430-621)

Protein A Chromatography

Chromatin Binding Proteins, DNA/RNA Binding, Epigenetics and Nuclear Signaling, Transcription, Transcription Factors

Transcription coactivator that binds to the 5'-AATA[CT]- 3' core sequence and plays a key role in adipogenesis and liver development. Acts by forming a complex with phosphorylated PHF2, which mediates demethylation at Lys-336, leading to target the PHF2-ARID5B complex to target promoters, where PHF2 mediates demethylation of dimethylated 'Lys-9' of histone H3 (H3K9me2), followed by transcription activation of target genes. The PHF2- ARID5B complex acts as a coactivator of HNF4A in liver. Required for adipogenesis: regulates triglyceride metabolism in adipocytes by regulating expression of adipogenic genes. Overexpression leads to induction of smooth muscle marker genes, suggesting that it may also act as a regulator of smooth muscle cell differentiation and proliferation. Represses the cytomegalovirus enhancer.

Boster Bio Anti-MRF2 ARID5B Antibody (Catalog# A02880). Tested in WB application(s). This antibody reacts with Human.

Widely expressed, including in liver (at protein level).