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Anti-p62Dok(Ab-398) DOK1 Antibody

Anti-p62Dok(Ab-398) DOK1 Antibody

ArtNr	BOS-A03039
Hersteller	Boster
Menge	100 ul
Kategorie	Neuroscience Metabolism Diabetes Cholesterol & Lipid Metabolism Regulation of Appetite Protein Aggregation, Clearance & Misfolding Antibodies Immunohistochemistry Western Blot Immunofluorescence Primary Antibodies
Typ	Antibody
Format	Liquid
Applikationen	WB, IF, IHC
Specific against	Human (Homo sapiens)
Host	Rabbit
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	Docking protein 1;Downstream of tyrosine kinase 1;p62 (dok);pp62;DOK1;
Lieferbar
Manufacturer - Category	Primary Antibodies
Storage Conditions	Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Observed Molecular Weight	52392 MW
Clonality	Polyclonal
Application Details	Predicted MW: 62kd Western blotting: 1:500~1:1000 Immunohistochemistry: 1:50~1:100 Immunofluorescence: 1:100~1:200
Manufacturer - Gene Name	DOK1
Gene Full Name	Docking protein 1
Background	DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK1 appears to be a negative regulator of the insulin signaling pathway. Modulates integrin activation by competing with talin for the same binding site on ITGB3. Michael J. Wick, et, al. (2001) J. Biol. Chem; 276: 42843 - 42850. Paul D. Simoncic, et, al. (2006) Mol. Cell. Biol; 26: 4149 - 4160. Nadia Dub
Immunogen	Peptide sequence around aa.396~400 (P-I-Y-D-E) derived from Human p62Dok.
Contents	Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification	Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Concentration	1 mg/ml
Manufacturer - Research Category	Adapters, Cancer, Cardiovascular, Cytoplasmic, G Protein Signaling, Lipid Signaling, Metabolism, Obesity, Platelets, Protein Phosphorylation, Ras Family, Signal Transduction, Signaling Pathway, Small G Proteins, Tyrosine Kinases
Protein Function	DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK1 appears to be a negative regulator of the insulin signaling pathway. Modulates integrin activation by competing with talin for the same binding site on ITGB3.
Subcellular Localization	Isoform 1: Cytoplasm. Nucleus.
Short Description	Boster Bio Anti-p62Dok(Ab-398) DOK1 Antibody (Catalog # A03039). Tested in WB, IHC, IF applications. This antibody reacts with Human.
Description	Boster Bio Anti-p62Dok(Ab-398) DOK1 Antibody (Catalog # A03039). Tested in WB, IHC, IF applications. This antibody reacts with Human.
Tissue Specificity	Expressed in pancreas, heart, leukocyte and spleen. Expressed in both resting and activated peripheral blood T-cells. Expressed in breast cancer.

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BOS-A03039-datasheet.pdf

BOS-A03039-safety-datasheet.pdf