Anti-IL-37 Antibody

ArtNr	BOS-A03607
Hersteller	Boster
Menge	100 ug
Kategorie	Neuroscience Neural Signaling Antibodies Western Blot Primary Antibodies
Typ	Antibody
Format	Liquid
Applikationen	WB
Specific against	Human (Homo sapiens)
Host	Rabbit
Isotype	IgG
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	Interleukin-37;FIL1 zeta;IL-1X;Interleukin-1 family member 7;IL-1F7;Interleukin-1 homolog 4;IL-1H;IL-1H4;Interleukin-1 zeta;IL-1 zeta;Interleukin-1-related protein;IL-1RP1;Interleukin-23;IL-37;IL37;FIL1Z, IL1F7, IL1H4, IL1RP1;
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Manufacturer - Category	Primary Antibodies
Manufacturer - Isotype	Rabbit IgG
Storage Conditions	Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.
Observed Molecular Weight	24126 MW
Clonality	Polyclonal
Application Details	Western blot: 2-4 µg/ml
Manufacturer - Gene Name	IL37
Gene Full Name	Interleukin-37
Immunogen	Full length recombinant IL-37 protein
Contents	100 μ g in 200 μ l PBS containing 0.05% BSA and 0.05% sodium azide.
Purification	Protein A Chromatography
Concentration	0.5-1mg/ml, actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.
Manufacturer - Research Category	Cytokines, Immunology, Innate Immunity, Interleukins, Macrophage/Inflammation
Protein Name	Interleukin-37
Protein Function	Suppressor of innate inflammatory and immune responses involved in curbing excessive inflammation. This function requires SMAD3. Suppresses, or reduces, proinflammatory cytokine production, including IL1A and IL6, as well as CCL12, CSF1, CSF2, CXCL13, IL1B, IL23A and IL1RN, but spares anti-inflammatory cytokines. Inhibits dendritic cell activation.
Subcellular Localization	Cytoplasm, cytosol. Nucleus. Secreted. Stimulation with IL1B leads to colocalization with SMAD3 mostly in perinuclear regions. Only the CASP1-cleaved mature form translocates into the nucleus upon LPS stimulation.
Short Description	Boster Bio Anti-IL-37 Antibody (Catalog# A03607). Tested in WB application(s). This antibody reacts with Human.
Description	Boster Bio Anti-IL-37 Antibody (Catalog# A03607). Tested in WB application(s). This antibody reacts with Human.
Tissue Specificity	In general, low constitutive expression, if any, in healthy tissues; high expression in inflammatory counterparts, including in synovial tissues from individuals with active rheumatoid arthritis. Isoform A, isoform B and isoform C are expressed in testis, colon, placenta, lung and lymph node. Isoform D and isoform E were found only in testis and bone marrow. Whereas only isoform A is found in brain, only isoform B in kidney and only isoform C in heart.

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BOS-A03607-datasheet.pdf

BOS-A03607-safety-datasheet.pdf