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Anti-Tyrosine-protein kinase FRK FRK Antibody

Anti-Tyrosine-protein kinase FRK FRK Antibody

ArtNr	BOS-A04075
Hersteller	Boster
Menge	100 ul
Kategorie	Neuroscience Metabolism Diabetes Molecular Targets for Neuroscience Antibodies Immunohistochemistry Western Blot Immunofluorescence Primary Antibodies
Typ	Antibody
Format	Liquid
Applikationen	WB, IF, IHC
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus), Rat (Rattus norvegicus)
Host	Rabbit
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	Tyrosine-protein kinase FRK;2.7.10.2;FYN-related kinase;Nuclear tyrosine protein kinase RAK;Protein-tyrosine kinase 5;FRK;PTK5, RAK;
Lieferbar
Manufacturer - Category	Primary Antibodies
Storage Conditions	Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Observed Molecular Weight	58254 MW
Clonality	Polyclonal
Application Details	Western blotting: 1:500~1:3000 Immunohistochemistry: 1:50~1:100 Immunofluorescence: 1:100~1:500
Manufacturer - Gene Name	FRK
Gene Full Name	Tyrosine-protein kinase FRK
Background	Non-receptor tyrosine-protein kinase that negatively regulates cell proliferation. Positively regulates PTEN protein stability through phosphorylation of PTEN on 'Tyr-336', which in turn prevents its ubiquitination and degradation, possibly by reducing its binding to NEDD4. May function as a tumor suppressor. Lee J., Gene 138:247-251(1994). Cance W.G., Cell Growth Differ. 5:1347-1355(1994). Zhang Y., Mol. Cell. Proteomics 4:1240-1250(2005).
Immunogen	Synthesized peptide derived from internal of human FRK.
Contents	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration	1 mg/ml
Manufacturer - Research Category	Cell Biology, Cell Cycle, Cell Cycle Inhibitors, Kinases/Phosphatases
Protein Function	Non-receptor tyrosine-protein kinase that negatively regulates cell proliferation. Positively regulates PTEN protein stability through phosphorylation of PTEN on 'Tyr-336', which in turn prevents its ubiquitination and degradation, possibly by reducing its binding to NEDD4. May function as a tumor suppressor.
Subcellular Localization	Cytoplasm. Nucleus. Predominantly found in the nucleus, with a small fraction found in the cell periphery.
Short Description	Boster Bio Anti-Tyrosine-protein kinase FRK FRK Antibody (Catalog # A04075). Tested in WB, IHC, IF applications. This antibody reacts with Human, Mouse, Rat.
Description	Boster Bio Anti-Tyrosine-protein kinase FRK FRK Antibody (Catalog # A04075). Tested in WB, IHC, IF applications. This antibody reacts with Human, Mouse, Rat.
Tissue Specificity	Predominantly expressed in epithelial derived cell lines and tissues, especially normal liver, kidney, breast and colon.

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BOS-A04075-datasheet.pdf

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