Anti-Twist2 Antibody

ArtNr	BOS-A04422
Hersteller	Boster
Menge	100 ul
Kategorie	Neuroscience Neural Development Antibodies Western Blot Primary Antibodies
Typ	Antibody
Format	Liquid
Applikationen	WB
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus), Rat (Rattus norvegicus)
Host	Rabbit
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	Twist-related protein 2;Class A basic helix-loop-helix protein 39;bHLHa39;Dermis-expressed protein 1;Dermo-1;TWIST2;BHLHA39, DERMO1;
Lieferbar
Manufacturer - Category	Primary Antibodies
Storage Conditions	Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Observed Molecular Weight	18124 MW
Clonality	Polyclonal
Application Details	Western blotting 1:100-1:500 Immunohistochemistry 1:100-1:500
Manufacturer - Gene Name	TWIST2
Gene Full Name	Twist-related protein 2
Background	Binds to the E-box consensus sequence 5'-CANNTG-3' as a heterodimer and inhibits transcriptional activation by MYOD1, MYOG, MEF2A and MEF2C. Also represses expression of proinflammatory cytokines such as TNFA and IL1B. Involved in postnatal glycogen storage and energy metabolism. Inhibits the premature or ectopic differentiation of preosteoblast cells during osteogenesis, possibly by changing the internal signal transduction response of osteoblasts to external growth factors.
Immunogen	Peptide sequence around aa.26~30(P-K-R-F-G) derived from Human Twist2.
Contents	Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification	Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Concentration	1 mg/ml
Manufacturer - Research Category	Domain Families, Epigenetics and Nuclear Signaling, Hlh/Leucine Zipper, Mesenchymal Stem Cells, Stem Cells, Transcription, Transcription Factors
Protein Function	Binds to the E-box consensus sequence 5'-CANNTG-3' as a heterodimer and inhibits transcriptional activation by MYOD1, MYOG, MEF2A and MEF2C. Also represses expression of proinflammatory cytokines such as TNFA and IL1B. Involved in postnatal glycogen storage and energy metabolism (By similarity). Inhibits the premature or ectopic differentiation of preosteoblast cells during osteogenesis, possibly by changing the internal signal transduction response of osteoblasts to external growth factors.
Subcellular Localization	Nucleus. Cytoplasm. Mainly nuclear during embryonic development. Cytoplasmic in adult tissues.
Short Description	Boster Bio Anti-Twist2 Antibody (Catalog # A04422). Tested in WB applications. This antibody reacts with Human, Mouse, Rat.
Description	Boster Bio Anti-Twist2 Antibody (Catalog # A04422). Tested in WB applications. This antibody reacts with Human, Mouse, Rat.
Tissue Specificity	In the embryo, highly expressed in chondrogenic cells. In embryonic skin, expressed in the undifferentiated mesenchymal layer beneath the epidermis which later develops into the dermis. Expressed in early myeloid cells but not in lymphoid cells in the liver. Expression also detected in the secretory ependymal epithelium of the choroid plexus primordium. In the adult, expressed in secreting glandular tissues and tubules.

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