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Anti-Beta TrCP2 FBXW11 Antibody

Anti-Beta TrCP2 FBXW11 Antibody

ArtNr	BOS-A05523
Hersteller	Boster
Menge	100 ug
Kategorie	Neuroscience Molecular Targets for Neuroscience Aging & Neurological Disorders Neural Adhesion Molecules Antibodies Western Blot Primary Antibodies
Typ	Antibody
Format	Liquid
Applikationen	WB, ELISA
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus)
Host	Rabbit
Isotype	IgG
Dry ice	Yes
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	beta TrCP2, BTRCP2, F-box/WD repeat-containing protein 11, beta Transducin Repeat Containing Protein 2, BTRC2, F-box and WD-40 Domain Protein 1B, F-box Protein FBW1B, FBW1B, FBXW1B, Homologous to Slimb protein, HOS, FBXW11
Lieferbar
Manufacturer - Category	Primary Antibodies
Storage Conditions	Store vial at -20°C prior to opening. Aliquot contents and freeze at -20°C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4°C as an undiluted liquid. Dilute only prior to immediate use. Expiration date is one (1) year from date of opening.
Observed Molecular Weight	62091 MW
Manufacturer - Format	Liquid (sterile filtered)
Clonality	Polyclonal
Application notes	This affinity purified antibody has been tested for use in ELISA and western blotting.
Application Details	ELISA: 1:10, 000 – 1:100, 000 IF Microscopy: User optimized WB: 1:200 to 1:1, 000
Manufacturer - Gene Name	FBXW11
Gene Full Name	F-box/WD repeat-containing protein 11
Background	This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbws class and, in addition to an F-box, contains multiple WD40 repeats. This gene contains at least 14 exons, and its alternative splicing generates 3 transcript variants diverging at the presence/absence of two alternate exons.
Immunogen	This affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to a region near the N-terminal of human ßTrCP2 protein.
Contents	0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2, 0.01% (w/v) Sodium Azide
Purification	This product was affinity purified from monospecific antiserum by immunoaffinity chromatography. This antibody reacts with human ßTrCP2 protein. A BLAST analysis was used to suggest cross-reactivity with ßTrCP2 from human, mouse, dog, bovine, chimpanzee, chicken and horse based on a 100% homology with the immunizing sequence. Cross-reactivity with ßTrCP2 from other sources has not been determined.
Concentration	0.8 mg/mL by UV absorbance at 280 nm
Protein Function	Substrate recognition component of a SCF (SKP1-CUL1-F- box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins. SCF (FBXW11) mediates the ubiquitination of phosphorylated CTNNB1 and participates in Wnt signaling. SCF (FBXW11) mediates the ubiquitination of phosphorylated NFKBIA, which degradation frees the associated NFKB1 to translocate into the nucleus and to activate transcription. SCF (FBXW11) mediates the ubiquitination of IFNAR1. SCF (FBXW11) mediates the ubiquitination of CEP68; this is required for centriole separation during mitosis (PubMed:25503564). Involved in the oxidative stress-induced a ubiquitin-mediated decrease in RCAN1. Mediates the degradation of CDC25A induced by ionizing radiation in cells progressing through S phase and thus may function in the intra-S- phase checkpoint. Has an essential role in the control of the clock-dependent transcription via degradation of phosphorylated PER1 and phosphorylated PER2. Is target of human immunodeficiency virus type 1 (HIV-1) protein VPU to polyubiquitinate and deplete BST2 from cells and antagonize its antiviral action.
Subcellular Localization	Cytoplasm. Nucleus.
Short Description	Boster Bio Anti-Beta TrCP2 FBXW11 Antibody (Catalog # A05523). Tested in ELISA, WB applications. This antibody reacts with Human, Mouse.
Description	Boster Bio Anti-Beta TrCP2 FBXW11 Antibody (Catalog # A05523). Tested in ELISA, WB applications. This antibody reacts with Human, Mouse.
Predicted Reactivity	Bovine, Canine, Chicken, Monkey

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