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Anti-Cyclin F CCNF Antibody

Anti-Cyclin F CCNF Antibody

ArtNr	BOS-A06781
Hersteller	Boster
Menge	100 ul
Kategorie	Oncology Neuroscience Neural Lineage Markers Antibodies By Cell Type Blastoma Carcinoma Cell Biology Cell Status Immunohistochemistry Western Blot Proliferation Primary Antibodies By Organ Bladder Cancer
Typ	Antibody
Format	Liquid
Applikationen	WB, IHC
Specific against	Human (Homo sapiens)
Host	Rabbit
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	Cyclin-F;F-box only protein 1;CCNF;FBX1, FBXO1;
Lieferbar
Manufacturer - Category	Primary Antibodies
Storage Conditions	Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Observed Molecular Weight	87640 MW
Clonality	Polyclonal
Application Details	Western blotting: 1:500~1:3000 Immunohistochemistry: 1:50~1:100
Manufacturer - Gene Name	CCNF
Gene Full Name	Cyclin-F
Background	Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of CP110 during G2 phase, thereby acting as an inhibitor of centrosome reduplication. Tsz Kan Fung, J. Biol. Chem., Sep 2002; 277: 35140 - 35149. Michael T. Tetzlaff, Mol. Cell. Biol., Mar 2004; 24: 2487 - 2498. Cain H. Yam, Mol. Cell. Biol., Jan 1999; 19: 635 - 645. Michael T. Tetzlaff, PNAS, Mar 2004; 101: 3338 - 3345.
Immunogen	Synthesized peptide derived from human Cyclin F.
Contents	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration	1 mg/ml
Manufacturer - Research Category	Cell Biology, Cell Cycle
Protein Function	Substrate recognition component of a SCF (SKP1-CUL1-F- box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of CP110 during G2 phase, thereby acting as an inhibitor of centrosome reduplication.
Subcellular Localization	Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Localization in the centrosome is rare in S phase cells and increases in G2 cells, Localizes on both the mother and daughter centrioles. Localization to centrosomes is not dependent on CP110. Also localizes to the nucleus.
Short Description	Boster Bio Anti-Cyclin F CCNF Antibody (Catalog # A06781). Tested in WB, IHC applications. This antibody reacts with Human.
Description	Boster Bio Anti-Cyclin F CCNF Antibody (Catalog # A06781). Tested in WB, IHC applications. This antibody reacts with Human.
Tissue Specificity	Widely expressed.

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BOS-A06781-datasheet.pdf

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