Hersteller |
Boster
|
Kategorie |
|
Typ |
Antibody |
Specific against |
Human, Mouse, Monkey |
Isotype |
IgG |
Format |
Liquid |
Applikationen |
WB, IF, ELISA, IHC-P |
Menge |
100ul |
Host |
Rabbit |
ArtNr |
BOS-A20019 |
Targets |
RAD51B |
eClass 6.1 |
32160702 |
eClass 9.0 |
32160702 |
Lieferbar |
|
Manufacturers Product Category |
Primary Antibodies |
Manufacturers Research Category |
DNA/RNA, DNA Damage & Repair, Epigenetics and Nuclear Signaling |
Short Description |
Boster Bio Anti-RAD51L1 RAD51B Antibody (Catalog# A20019). Tested in WB, IHC-P, IF (paraffin), ELISA applications. This antibody reacts with Human, Mouse, Monkey. |
Description |
Boster Bio Anti-RAD51L1 RAD51B Antibody (Catalog# A20019). Tested in WB, IHC-P, IF (paraffin), ELISA applications. This antibody reacts with Human, Mouse, Monkey. |
Gene Name |
RAD51B |
Clonality |
Polyclonal |
Concentration |
0.5-1mg/ml, actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure. |
Contents |
PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
Application Details |
Western Blot, 1:500 - 1:2000 Immunohistochemistry, 1:100 - 1:300 ELISA, 1:40000 Not yet tested in other applications. |
Immunogen |
A peptide derived from human RAD51L1. Immunogen sequence location: 201-250 |
Purification |
The antibody was purified from rabbit antiserum by affinity-chromatography using immunogen. |
Storage |
Store at -20°C for one year. For short-term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles. |
Gene Full Name |
DNA repair protein RAD51 homolog 2 |
Molecular Weight |
42196 MW |
Protein Function |
Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents. May promote the assembly of presynaptic RAD51 nucleoprotein filaments. Binds single-stranded DNA and double-stranded DNA and has DNA-dependent ATPase activity. Part of the RAD21 paralog protein complex BCDX2 which acts in the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, BCDX2 acts downstream of BRCA2 recruitment and upstream of RAD51 recruitment. BCDX2 binds predominantly to the intersection of the four duplex arms of the Holliday junction and to junction of replication forks. The BCDX2 complex was originally reported to bind single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA. The BCDX2 subcomplex RAD51B:RAD51C exhibits single-stranded DNA-dependent ATPase activity suggesting an involvement in early stages of the HR pathway. |
Subcellular Localization |
Nucleus. |
Tissue Specificity |
Expressed in a wide range of tissues. |
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