Antibodies

Anti-RAD51L1 Antibody

Hersteller Boster
Kategorie
Typ Antibody
Specific against other
Applikationen WB, IHC
Menge 100ug/vial
Host Rabbit
ArtNr BOS-A20019
eClass 6.1 32160702
eClass 9.0 32160702
Lieferbar
Gene name
RAD51B
Clonality
Polyclonal
Conjugate
No
Contents
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Description
Polyclonal antibody for RAD51L1/RAD51B detection. Host: Rabbit.Size: 100ug/vial. Tested applications: IHC. Reactive species: Human. RAD51L1/RAD51B information: Molecular Weight: 42196 MW; Subcellular Localization: Nucleus ; Tissue Specificity: Expressed in a wide range of tissues.
Uniprot ID
O15315
Immunogen
A peptide derived from human RAD51L1. Immunogen sequence location: 201-250
Purification
The antibody was purified from rabbit antiserum by affinity-chromatography using immunogen.
Storage
At -20° C for one year. After reconstitution, at 4° C for one month. It can also be aliquotted and stored frozen at -20° C for a longer time.Avoid repeated freezing and thawing.
Application details
User need to optimize the dilution ratio for this antibody
Reactivity
Human, Mouse
Research category
|epigenetics and nuclear signaling|dna / rna|dna damage & repair|homologous recomb.
Synonyms
DNA repair protein RAD51 homolog 2, R51H2, RAD51 homolog B, Rad51B, RAD51-like protein 1, RAD51B, RAD51L1, REC2,
Molecular weight
42196 MW
Protein function
Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents. May promote the assembly of presynaptic RAD51 nucleoprotein filaments. Binds single-stranded DNA and double-stranded DNA and has DNA-dependent ATPase activity. Part of the RAD21 paralog protein complex BCDX2 which acts in the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, BCDX2 acts downstream of BRCA2 recruitment and upstream of RAD51 recruitment. BCDX2 binds predominantly to the intersection of the four duplex arms of the Holliday junction and to junction of replication forks. The BCDX2 complex was originally reported to bind single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA. The BCDX2 subcomplex RAD51B:RAD51C exhibits single-stranded DNA-dependent ATPase activity suggesting an involvement in early stages of the HR pathway. .

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Menge: 100ug/vial
Lieferbar: In stock
Listenpreis: 386,89 €
Preis: 386,89 €
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