|
Hersteller |
Boster
|
|
Kategorie |
|
|
Typ |
Antibody |
|
Specific against |
other |
|
Applikationen |
WB, IHC |
|
Menge |
100ug/vial |
|
Host |
Rabbit |
|
ArtNr |
BOS-A20019 |
|
eClass 6.1 |
32160702 |
|
eClass 9.0 |
32160702 |
|
Lieferbar |
 |
| Gene name |
RAD51B |
| Clonality |
Polyclonal |
| Conjugate |
No |
| Contents |
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Description |
Polyclonal antibody for RAD51L1/RAD51B detection. Host: Rabbit.Size: 100ug/vial. Tested applications: IHC. Reactive species: Human. RAD51L1/RAD51B information: Molecular Weight: 42196 MW; Subcellular Localization: Nucleus ; Tissue Specificity: Expressed in a wide range of tissues. |
| Uniprot ID |
O15315 |
| Immunogen |
A peptide derived from human RAD51L1. Immunogen sequence location: 201-250 |
| Purification |
The antibody was purified from rabbit antiserum by affinity-chromatography using immunogen. |
| Storage |
At -20° C for one year. After reconstitution, at 4° C for one month. It can also be aliquotted and stored frozen at -20° C for a longer time.Avoid repeated freezing and thawing. |
| Application details |
User need to optimize the dilution ratio for this antibody |
| Reactivity |
Human, Mouse |
| Research category |
|epigenetics and nuclear signaling|dna / rna|dna damage & repair|homologous recomb. |
| Synonyms |
DNA repair protein RAD51 homolog 2, R51H2, RAD51 homolog B, Rad51B, RAD51-like protein 1, RAD51B, RAD51L1, REC2, |
| Molecular weight |
42196 MW |
| Protein function |
Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents. May promote the assembly of presynaptic RAD51 nucleoprotein filaments. Binds single-stranded DNA and double-stranded DNA and has DNA-dependent ATPase activity. Part of the RAD21 paralog protein complex BCDX2 which acts in the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, BCDX2 acts downstream of BRCA2 recruitment and upstream of RAD51 recruitment. BCDX2 binds predominantly to the intersection of the four duplex arms of the Holliday junction and to junction of replication forks. The BCDX2 complex was originally reported to bind single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA. The BCDX2 subcomplex RAD51B:RAD51C exhibits single-stranded DNA-dependent ATPase activity suggesting an involvement in early stages of the HR pathway. . |
