Anti-Dematin DMTN Antibody

Primary Antibodies

Store at -20°C for one year. For short-term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Polyclonal

DMTN

A peptide derived from human Dematin. Immunogen sequence location: 356-405

The antibody was purified from rabbit antiserum by affinity-chromatography using immunogen.

Membrane-cytoskeleton-associated protein with F-actin- binding activity that induces F-actin bundles formation and stabilization. Its F-actin-bundling activity is reversibly regulated upon its phosphorylation by the cAMP-dependent protein kinase A (PKA). Binds to the erythrocyte membrane glucose transporter-1 SLC2A1/GLUT1, and hence stabilizes and attaches the spectrin-actin network to the erythrocytic plasma membrane. Plays a role in maintaining the functional integrity of PKA-activated erythrocyte shape and the membrane mechanical properties. Plays also a role as a modulator of actin dynamics in fibroblasts; acts as a negative regulator of the RhoA activation pathway. In platelets, functions as a regulator of internal calcium mobilization across the dense tubular system that affects platelet granule secretion pathways and aggregation. Also required for the formation of a diverse set of cell protrusions, such as filopodia and lamellipodia, necessary for platelet cell spreading, motility and migration. Acts as a tumor suppressor and inhibits malignant cell transformation.

Boster Bio Anti-Dematin DMTN Antibody (Catalog# A30444). Tested in WB, IHC-P, IF, ICC, ELISA applications. This antibody reacts with Human, Mouse.

Expressed in platelets (at protein level).Expressed in heart, brain, lung, skeletal muscle, and kidney.