Anti-H4K20me3 Antibody

At -20°C for one year, at 4°C for one month. Avoid repeated freezing and thawing.

Polyclonal

Histones are the main constituents of the protein part of chromosomes of eukaryotic cells. They are rich in the amino acids arginine and lysine and have been greatly conserved during evolution. Histones pack the DNA into tight masses of chromatin. Two core histones of each class H2A, H2B, H3 and H4 assemble and are wrapped by 146 base pairs of DNA to form one octameric nucleosome. Histone tails undergo numerous post-translational modifications, which either directly or indirectly alter chromatin structure to facilitate transcriptional activation or repression or other nuclear processes. In addition to the genetic code, combinations of the different histone modifications reveal the so-called a€œhistone codea€. Histone methylation and demethylation is dynamically regulated by respectively histone methyl transferases and histone demethylases. H4K20me3 is a marker for heterochromatin.

Whole antiserum from rabbit containing 0.05% azide.

|epigenetics and nuclear signaling|histones|h4|unmodified| epigenetics and nuclear signaling|chip'ing antibodies