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Anti-E-Cadherin 1 (CDH1) Rabbit Monoclonal Antibody, Clone#RM244

Anti-E-Cadherin 1 (CDH1) Rabbit Monoclonal Antibody, Clone#RM244

ArtNr	BOS-M00063-3
Hersteller	Boster
Menge	100 ul
Kategorie	Oncology Neuroscience Neural Adhesion Molecules Antibodies By Cell Type Carcinoma Immunohistochemistry Western Blot Primary Antibodies By Organ Bladder Cancer
Typ	Antibody Monoclonal
Format	Liquid
Applikationen	WB, IHC
Clon	RM244
Specific against	Human (Homo sapiens)
Host	Rabbit
Isotype	IgG
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Alias	Cadherin-1,CAM 120/80,Epithelial cadherin,E-cadherin,Uvomorulin,CD324,E-Cad/CTF1,E-Cad/CTF2,E-Cad/CTF3,CDH1,CDHE,UVO
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Manufacturer - Category	Primary Antibodies, Rabbit Monoclonal Antibodies
Storage Conditions	Store at -20°C for one year. Avoid repeated freeze-thaw cycles.
Molecular Weight	97456 MW
Clonality	Monoclonal
Application Details	Immunohistochemistry (IHC): 1:500-1:1000 dilution WB: 1:1000-1:2000 dilution.
Gene Name	CDH1
Gene Full Name	Cadherin-1
Manufacturer - Specificity	This antibody reacts to human E-cadherin (Cadherin-1).
Immunogen	A peptide corresponding to Cadherin-1
Contents	50% Glycerol/PBS with 1% BSA and 0.09% sodium azide
Purification	Protein A affinity purified from an animal origin-free culture supernatant
Concentration	0.5-1mg/ml, actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.
Manufacturer - Research Category	Cadherins, Calcium Binding Proteins, Calcium Signaling, Cancer, Cell Adhesion, Cytoskeleton/ECM, Invasion/Microenvironment, Signal Transduction, Signaling Pathway
Protein Function	Cadherins are calcium-dependent cell adhesion proteins (PubMed:11976333). They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells (PubMed:11976333). Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7.
Subcellular Localization	Cell junction. Cell membrane; Single-pass type I membrane protein. Endosome. Golgi apparatus, trans-Golgi network. Colocalizes with DLGAP5 at sites of cell-cell contact in intestinal epithelial cells. Anchored to actin microfilaments through association with alpha-, beta- and gamma-catenin. Sequential proteolysis induced by apoptosis or calcium influx, results in translocation from sites of cell-cell contact to the cytoplasm. Colocalizes with RAB11A endosomes during its transport from the Golgi apparatus to the plasma membrane.
Description	Boster Bio Anti-E-Cadherin 1 (CDH1) Rabbit Monoclonal Antibody, Clone#RM244 (Catalog # M00063-3). Tested in IHC, WB applications. This antibody reacts with Human.
Tissue Specificity	Non-neural epithelial tissues.
Manufacturer - Cross Reactivity	This antibody reacts to human E-cadherin (Cadherin-1).

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BOS-M00063-3-datasheet.pdf

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