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Anti-PD-L1 (CD274) (B7-H1) Rabbit Monoclonal Antibody, Clone#RM320

Anti-PD-L1 (CD274) (B7-H1) Rabbit Monoclonal Antibody, Clone#RM320

ArtNr	BOS-M00109-1
Hersteller	Boster
Menge	100 ul
Kategorie	Oncology Antibodies By Cell Type Blastoma Carcinoma Glioma Hematology Lymphoma Melanoma Sarcoma Mesothelioma Immunohistochemistry Western Blot Immunocytochemistry Primary Antibodies Immunochemistry
Typ	Antibody Monoclonal
Format	Liquid
Applikationen	WB, IHC, ICC
Clon	RM320
Specific against	Human (Homo sapiens)
Host	Rabbit
Isotype	IgG
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Alias	Programmed cell death 1 ligand 1,PD-L1,PDCD1 ligand 1,Programmed death ligand 1,B7 homolog 1,B7-H1,CD274,Cd274,B7h1,Pdcd1l1,Pdcd1lg1,Pdl1
Lieferbar
Manufacturer - Category	Primary Antibodies, Rabbit Monoclonal Antibodies
Storage Conditions	Store at -20°C for one year. Avoid repeated freeze-thaw cycles.
Molecular Weight	32780 MW
Clonality	Monoclonal
Application Details	Immunohistochemistry (IHC): 1:200-1:1000 dilution WB: 1:500-1:1000 dilution Immunocytochemistry (ICC): 1:200-1:500 dilution
Gene Name	Cd274
Gene Full Name	Programmed cell death 1 ligand 1
Manufacturer - Specificity	This antibody reacts to human PD-L1 (CD274) (B7-H1)
Immunogen	A peptide corresponding to the C-terminus of human PD-L1
Contents	50% Glycerol/PBS with 1% BSA and 0.09% sodium azide
Purification	Protein A affinity purified from an animal origin-free culture supernatant
Concentration	0.5-1mg/ml, actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.
Manufacturer - Research Category	Autoimmune, Cancer, Cell Type Markers, Immune System Diseases, Immunology, Tumor Antigens, Tumor Biomarkers, Tumor Immunology, Tumor-Associated Antigens
Protein Function	Plays a critical role in induction and maintenance of immune tolerance to self. As a ligand for the inhibitory receptor PDCD1, modulates the activation threshold of T-cells and limits T- cell effector response (PubMed:11238124). The PDCD1-mediated inhibitory pathway is exploited by tumors to attenuate anti-tumor immunity and facilitate tumor survival (By similarity). May costimulate helper T-cell subsets through a yet unknown activating receptor (PubMed:11015443, PubMed:12719480).
Subcellular Localization	Cell membrane; Single-pass type I membrane protein. Early endosome membrane; Single-pass type I membrane protein. Recycling endosome membrane; Single-pass type I membrane protein.
Description	Boster Bio Anti-PD-L1 (CD274) (B7-H1) Rabbit Monoclonal Antibody, Clone#RM320 (Catalog # M00109-1). Tested in IHC, WB, ICC applications. This antibody reacts with Human.
Tissue Specificity	Highly expressed in the heart, thymus, skeletal muscle, and lung. Weakly expressed in the kidney, spleen, thyroid, and liver. Expressed on activated dendritic cells, B- cells and macrophages. Expressed in numerous tumor cells lines of lymphoid origin.
Manufacturer - Cross Reactivity	This antibody reacts to human PD-L1 (CD274) (B7-H1)

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

Arbeitsanleitung (Data Sheet) anfordern

BOS-M00109-1-datasheet.pdf

BOS-M00109-1-safety-datasheet.pdf