Anti-IL-33 Antibody (Monoclonal, Nessy-1)

Primary Antibodies, Monoclonal Antibodies, 2279

30759 MW

Recognizes pro-IL-33 (precursor) and mature IL-33.

IL33

Interleukin 33 (IL-33) is a cytokine belonging to the IL-1 superfamily. The IL33 gene maps to chromosome 9p24.1 by using of genomic database analysis. Recombinant mature human IL33 bound to ST2. The induction of type 2 cytokines by IL-33 in vivo is believed to induce the severe pathological changes observed in mucosal organs following administration of IL-33. IL33, an alarmin released from necrotic cells, is necessary for potent CD8 + T cell (CTL) responses to replicating, prototypic RNA, and DNA viruses in mice. IL33 prevented the downregulation of CXCR2 and inhibition of chemotaxis induced by activation of TLR4, and found that IL33 reverses the TLR4-induced reduction of CXCR2 expression via the inhibition of expression of GRK2.

Liquid. In PBS.

1 mg/mL

Interleukin-33 (IL33)

Nucleus. Chromosome. Cytoplasmic vesicle, secretory vesicle. Secreted. Associates with heterochromatin and mitotic chromosomes. Translocation from the nucleus occurs upon biomechanical strain, depends on an intact microtubule network, and is ATP-dependent.

Boster Bio Anti-IL-33 Antibody (Monoclonal, Nessy-1) (Catalog# M00113). Tested in ELISA, IHC-P, IP, WB application(s). This antibody reacts with Human, Mouse, Rat.