Anti-Histone H2AX H2AFX Rabbit Monoclonal Antibody, Clone#RM214

Rabbit IgG

15145 MW

WB: 0.5 ug/mL – 2 ug/mL

ICC: 1 ug/mL - 2 ug/mL

ELISA: 0.2 ug/mL - 1 ug/mL

Luminex: 0.2 ug/mL – 1 ug/mL.

Histone H2AX

50% Glycerol/PBS with 1% BSA and 0.09% sodium azide

1 mg/mL

Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Required for checkpoint-mediated arrest of cell cycle progression in response to low doses of ionizing radiation and for efficient repair of DNA double strand breaks (DSBs) specifically when modified by C- terminal phosphorylation.

Boster Bio Anti-Histone H2AX H2AFX Rabbit Monoclonal Antibody, Clone#RM214 (Catalog # M00241-2). Tested in WB, ICC. ELISA, Luminex applications. This antibody reacts with Vertebrates.