Anti-PSer 139 Histone H2AX H2AFX Antibody (Monoclonal, 9F3)

Store at -20°C for long-term storage. Avoid freeze/thaw cycles.

Monoclonal

H2AFX

Synthetic peptide corresponding to a portion of human Histone H2AX phosphorylated at Ser139

Protein G affinity purified.

2339, DNA/RNA, DNA Damage Response, Epigenetics and Nuclear Signaling, Histones

Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Required for checkpoint-mediated arrest of cell cycle progression in response to low doses of ionizing radiation and for efficient repair of DNA double strand breaks (DSBs) specifically when modified by C- terminal phosphorylation.

Boster Bio Anti-PSer 139 Histone H2AX H2AFX Antibody (Monoclonal, 9F3) (Catalog# M00241). Tested in WB application(s). This antibody reacts with Human, Mouse, Rat, Bovine, Chicken, Dog, Guinea pig, Hamster, Monkey, Porcine, Rabbit, Sheep.