« Zurück
Startseite /
Anti-MITF Antibody (Monoclonal, ABM1H91)

Anti-MITF Antibody (Monoclonal, ABM1H91)

ArtNr	BOS-M00269
Hersteller	Boster
Menge	100 ug
Kategorie	Oncology Antibodies By Cell Type Melanoma Immunohistochemistry Western Blot Primary Antibodies
Typ	Antibody Monoclonal
Format	Liquid
Applikationen	WB, IHC
Clon	ABM1H91
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus)
Host	Mouse
Isotype	IgG1 Kappa
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Alias	Microphthalmia-associated transcription factor,Class E basic helix-loop-helix protein 32,bHLHe32,MITF,BHLHE32
Lieferbar
Manufacturer - Category	Primary Antibodies
Storage Conditions	Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.
Molecular Weight	58795 MW
Clonality	Monoclonal
Application Details	Western blot: 2-4 µg/ml, IHC: 10 µg/ml
Gene Name	MITF
Gene Full Name	Microphthalmia-associated transcription factor
Immunogen	A partial length recombinant MITF protein (amino acids 150-427)
Contents	100 μ g in 200 μ l PBS containing 0.05% BSA and 0.05% sodium azide.
Purification	Protein G Chromatography
Concentration	0.5-1mg/ml, actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.
Manufacturer - Research Category	2339, Domain Families, Epigenetics and Nuclear Signaling, Hlh/Leucine Zipper, Immunology, Innate Immunity, Transcription
Protein Name	Microphthalmia-associated transcription factor
Protein Function	Transcription factor that regulates the expression of genes with essential roles in cell differentiation, proliferation and survival. Binds to symmetrical DNA sequences (E-boxes) (5'- CACGTG-3') found in the promoters of target genes, such as BCL2 and tyrosinase (TYR). Plays an important role in melanocyte development by regulating the expression of tyrosinase (TYR) and tyrosinase-related protein 1 (TYRP1). Plays a critical role in the differentiation of various cell types, such as neural crest- derived melanocytes, mast cells, osteoclasts and optic cup-derived retinal pigment epithelium.
Subcellular Localization	Nucleus.
Description	Boster Bio Anti-MITF Antibody (Monoclonal, ABM1H91) (Catalog# M00269). Tested in IHC, WB application(s). This antibody reacts with Mouse, Human.
Tissue Specificity	Isoform M is exclusively expressed in melanocytes and melanoma cells. Isoform A and isoform H are widely expressed in many cell types including melanocytes and retinal pigment epithelium (RPE). Isoform C is expressed in many cell types including RPE but not in melanocyte-lineage cells. Isoform Mdel is widely expressed in melanocytes, melanoma cell lines and tissues, but almost undetectable in non-melanoma cell lines.

Hinweis: Die dargestellten Informationen und Dokumente (Bedienungsanleitung, Produktdatenblatt, Sicherheitsdatenblatt und Analysezertifikat) entsprechen unserem letzten Update und sollten lediglich der Orientierung dienen. Wir übernehmen keine Garantie für die Aktualität. Für spezifische Anforderungen bitten wir Sie, uns eine Anfrage zu stellen.

Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

Arbeitsanleitung (Data Sheet) anfordern

BOS-M00269-datasheet.pdf

BOS-M00269-safety-datasheet.pdf