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Anti-NFAT2 NFATC1 Rabbit Monoclonal Antibody

Anti-NFAT2 NFATC1 Rabbit Monoclonal Antibody

ArtNr	BOS-M00340
Hersteller	Boster
Menge	100 ul
Kategorie	Antibodies Flow Cytometry Western Blot Immunofluorescence Immunocytochemistry Primary Antibodies
Typ	Antibody Monoclonal
Format	Liquid
Applikationen	WB, FC, IF, ICC
Clon	ABDA-14
Specific against	Human (Homo sapiens)
Host	Rabbit
Isotype	IgG
Sensitivity	<2pg/ml
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Alias	Nuclear factor of activated T-cells, cytoplasmic 1;NF-ATc1;NFATc1;NFAT transcription complex cytosolic component;NF-ATc;NFATc;NFATC1;NFAT2, NFATC;
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Manufacturer - Category	Rabbit Monoclonal Antibodies
Manufacturer - Isotype	Rabbit IgG
Storage Conditions	Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Observed Molecular Weight	32 kDa
Calculated Molecular weight	101243 MW
Clonality	Monoclonal
Application Details	WB 1:500-1:2000 ICC/IF 1:50-1:200 FC 1:50
Manufacturer - Gene Name	NFATC1
Gene Full Name	Nuclear factor of activated T-cells, cytoplasmic 1
Immunogen	A synthesized peptide derived from human NFAT2
Contents	Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5 mg/ml BSA.
Purification	Affinity-chromatography
Reconstitution	Restore with deionized water (or equivalent) for reconstitution volume of 1.0 mL
Concentration	Actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.
Manufacturer - Research Category	Adaptive Immunity, Cardiogenesis, Cardiovascular, 2339, Epigenetics and Nuclear Signaling, Immunology, Non-CD, Nuclear Signaling, Nuclear Signaling Pathways, Signal Transduction, Signaling Pathway, T Cells, Transcription, Transcription Factors/Regulators
Protein Name	P2X purinoceptor 1
Protein Function	Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2 or IL-4 gene transcription. Also controls gene expression in embryonic cardiac cells. Could regulate not only the activation and proliferation but also the differentiation and programmed death of T-lymphocytes as well as lymphoid and non-lymphoid cells.
Subcellular Localization	Cytoplasm. Nucleus. Cytoplasmic for the phosphorylated form and nuclear after activation that is controlled by calcineurin-mediated dephosphorylation. Rapid nuclear exit of NFATC is thought to be one mechanism by which cells distinguish between sustained and transient calcium signals. The subcellular localization of NFATC plays a key role in the regulation of gene transcription.
Description	Boster Bio Anti-NFAT2 NFATC1 Rabbit Monoclonal Antibody catalog # M00340. Tested in WB, ICC/IF, Flow Cytometry applications. This antibody reacts with Human.
Tissue Specificity	Expressed in thymus, peripheral leukocytes as T-cells and spleen. Isoforms A are preferentially expressed in effector T-cells (thymus and peripheral leukocytes) whereas isoforms B and isoforms C are preferentially expressed in naive T- cells (spleen). Isoforms B are expressed in naive T-cells after first antigen exposure and isoforms A are expressed in effector T- cells after second antigen exposure. Isoforms IA are widely expressed but not detected in liver nor pancreas, neural expression is strongest in corpus callosum. Isoforms IB are expressed mostly in muscle, cerebellum, placenta and thymus, neural expression in fetal and adult brain, strongest in corpus callosum.

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

Arbeitsanleitung (Data Sheet) anfordern

BOS-M00340-datasheet.pdf

BOS-M00340-safety-datasheet.pdf