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Anti-PSD-95 DLG4 Rabbit Monoclonal Antibody, Clone#RM288

Anti-PSD-95 DLG4 Rabbit Monoclonal Antibody, Clone#RM288

ArtNr	BOS-M02128-1
Hersteller	Boster
Menge	100 ul
Kategorie	Neuroscience Molecular Targets for Neuroscience Neural Signaling Antibodies Immunohistochemistry Western Blot Primary Antibodies
Typ	Antibody Primary
Format	Liquid
Applikationen	WB, IHC
Clon	RM288
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus)
Host	Rabbit
Isotype	IgG
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	Disks large homolog 4;Postsynaptic density protein 95;PSD-95;Synapse-associated protein 90;SAP-90;SAP90;DLG4;PSD95;
Lieferbar
Manufacturer - Category	Primary Antibodies, Monoclonal Antibodies, Rabbit Monoclonal Antibodies, 2279
Manufacturer - Isotype	Rabbit IgG
Storage Conditions	Store at -20°C for one year. Avoid repeated freeze-thaw cycles.
Observed Molecular Weight	80495 MW
Clonality	Monoclonal
Application Details	Immunohistochemistry (IHC): 1:100-1:200 dilution WB: 1:1000-1:8000 dilution.
Manufacturer - Gene Name	DLG4
Gene Full Name	Disks large homolog 4
Immunogen	A peptide corresponding to the N-terminus of human PSD95
Contents	50% Glycerol/PBS with 1% BSA and 0.09% sodium azide
Purification	Protein A affinity purified from an animal origin-free culture supernatant
Concentration	0.5-1mg/ml, actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.
Manufacturer - Research Category	Adapters, Cell Type Marker, Intracellular Signaling, Neuron Marker, Neuroscience, Neurotransmission, Synapse Marker
Protein Function	Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B. Also regulates AMPA-type glutamate receptor (AMPAR) immobilization at postsynaptic density keeping the channels in an activated state in the presence of glutamate and preventing synaptic depression.
Subcellular Localization	Cell membrane; Lipid-anchor; Cytoplasmic side. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Cell junction, synapse. Cytoplasm. Cell projection, axon. High levels in postsynaptic density of neurons in the forebrain. Also in presynaptic region of inhibitory synapses formed by cerebellar basket cells on axon hillocks of Purkinje cells.
Short Description	Boster Bio Anti-PSD-95 DLG4 Rabbit Monoclonal Antibody, Clone#RM288 (Catalog # M02128-1). Tested in IHC, WB applications. This antibody reacts with Human, Mouse.
Description	Boster Bio Anti-PSD-95 DLG4 Rabbit Monoclonal Antibody, Clone#RM288 (Catalog # M02128-1). Tested in IHC, WB applications. This antibody reacts with Human, Mouse.
Tissue Specificity	Brain.
Predicted Reactivity	Rat

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BOS-M02128-1-datasheet.pdf

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