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Anti-Human ARSA DyLight® 550 conjugated Antibody(monoclonal, 4C10)

Anti-Human ARSA DyLight® 550 conjugated Antibody(monoclonal, 4C10)

ArtNr	BOS-M02583-Dyl550
Hersteller	Boster
Menge	100 ug/vial
Kategorie	Metabolism Cholesterol & Lipid Metabolism Antibodies Flow Cytometry Enzymes Other Fatty Acid Enzymes Primary Antibodies
Typ	Antibody Monoclonal
Format	Liquid
Applikationen	FC
Clon	4C10
Specific against	Human (Homo sapiens)
Host	Mouse
Isotype	IgG2a
Konjugat/Tag	DyLight 550
Sensitivity	>5000 cells
Citations	1. Fujii T; Kobayashi T; Honke K et al. (1992). Proteolytic processing of human lysosomal arylsulfatase A. Biochim. Biophys. Acta 1122 (1): 93–8. 2. Kondo R; Wakamatsu N; Yoshino H et al. (1991).Identification of a mutation in the arylsulfatase A gene of a patient with adult-type metachromatic leukodystrophy. Am. J. Hum. Genet. 48 (5): 971–8. 3. Matzner U, Herbst E, Hedayati KK, Lüllmann-Rauch R, Wessig C, Schröder S, Eistrup C, Möller C, Fogh J, Gieselmann V (May 2005). Enzyme replacement improves nervous system pathology and function in a mouse model for metachromatic leukodystrophy. Hum. Mol. Genet. 14 (9): 1139–52.
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Alias	Arylsulfatase A,ASA,Cerebroside-sulfatase,Arylsulfatase A component B,Arylsulfatase A component C,ARSA
Lieferbar
Manufacturer - Category	Primary Antibodies
Storage Conditions	At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Observed Molecular weight	39 kDa
Clonality	Monoclonal
Application Details	Flow Cytometry (Fixed), 1-3μg/1x10⁶ cells
Gene Name	ARSA
Gene Full Name	arylsulfatase A
Manufacturer - Specificity	No cross reactivity with other proteins.
Background	Arylsulfatase A (ARSA) is an enzyme that breaks down sulfatides, namely cerebroside 3-sulfate intocerebroside and sulfate. In humans, arylsulfatase A is encoded by the ARSA gene. ARSA is mapped to 22q13.33. The protein encoded by this gene hydrolyzes cerebroside sulfate to cerebroside and sulfate. Defects in this gene lead to metachromatic leucodystrophy (MLD), a progressive demyelination disease which results in a variety of neurological symptoms and ultimately death. Alternatively spliced transcript variants have been described for this gene.
Immunogen	A synthetic peptide corresponding to a sequence at the C-terminus of human ARSA, different from the related mouse sequence by six amino acids.
Contents	Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
Concentration	0.5mg/ml
Manufacturer - Research Category	Cancer, Cell Biology, Cell Death, Metabolism, Metabolism Processes, Neurodegenerative Disease, Neurology Process, Neuroscience, Organelles, Pathways and Processes, Signal Transduction, Subcellular Markers, Tags & Cell Markers
Protein Function	Hydrolyzes cerebroside sulfate.
Subcellular Localization	Lysosome.
Description	Boster Bio Anti-Human ARSA DyLight® 550 conjugated Antibody (monoclonal, 4C10) catalog # M02583-Dyl550. Tested in Flow Cytometry applications. This antibody reacts with Human.
Manufacturer - Cross Reactivity	No cross-reactivity with other proteins.

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BOS-M02583-Dyl550-datasheet.pdf

BOS-M02583-Dyl550-safety-datasheet.pdf