Anti-Acetyl-Histone H3 (Lys56) H3F3A Rabbit Monoclonal Antibody, Clone#RM179

WB, ICC, IHC, ELISA, Luminex

Store at -20°C for one year. Avoid repeated freeze-thaw cycles.

Monoclonal

H3F3A

This antibody reacts to Histone H3 acetylated at Lysine 56 (K56ac). No cross-reactivity with other acetylated Lysines in histone H3.

50% Glycerol/PBS with 1% BSA and 0.09% sodium azide

1 mg/mL

Variant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes. Constitutes the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin independently of DNA synthesis. Deposited at sites of nucleosomal displacement throughout transcribed genes, suggesting that it represents an epigenetic imprint of transcriptionally active chromatin. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

Boster Bio Anti-Acetyl-Histone H3 (Lys56) H3F3A Rabbit Monoclonal Antibody, Clone#RM179 (Catalog # M06819-24). Tested in WB, ICC, IHC, ELISA, Luminex applications. This antibody reacts with Human, Vertebrates.