Anti-Pdcd4 phospho S457 Monoclonal Antibody

Monoclonal Antibodies, Primary Antibodies

Monoclonal

ELISA: 1:20, 000 - 1:100, 000
IP: 1:1, 000 - 1:5, 000
WB: 1:2, 000 - 1:10, 000

Programmed cell death 4 (Pdcd4) is a novel tumor suppressor. Pdcd4 directly inhibits the helicase activity of eukaryotic translation initiation factor 4A (eIF4A), a component of the translation initiation complex. Pdcd4 also suppresses the transactivation of activator protein-1 (AP-1)-responsive promoters by c-Jun. Pdcd4 contains two Akt phosphorylation sites, one at Ser67 and the other at Ser457. The phosphorylation of Pdcd4 by Akt causes nuclear translocation of Pdcd4 and a significant decrease in the ability of Pdcd4 to interfere with the transactivation of AP-1-responsive promoters by c-Jun.

0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2, 10 mg/mL Bovine Serum Albumin (BSA) - Immunoglobulin and Protease free, 0.01% (w/v) Sodium Azide

Restore with deionized water (or equivalent) for reconstitution volume of 100 µL

Apoptosis, Cancer, Cell Biology, Cell Cycle, Cell Cycle Inhibitors, Cell Death, Epigenetics and Nuclear Signaling, Invasion/Microenvironment, Nucleus, Transcription

Boster Bio Anti-Pdcd4 phospho S457 Monoclonal Antibody (Catalog # MP01105-1). Tested in ELISA, WB applications. This antibody reacts with Human, Mouse, Rat, Xenopus.