Anti-Phospho-GABAA Receptor beta3 (Ser408/409) Antibody

Primary Antibodies

54166 MW

Specific for endogenous levels of the ~53 kDa GABAA receptor ?3 subunit phosphorylated at Ser408/409. Immunolabeling is blocked by preadsorption with the phosphopeptide used as antigen, but not by the corresponding non-phosphopeptide.

GABRB3

Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system. There are two major classes of GABA receptors: the GABA-A and the GABA-B subtype of receptors. GABA-A-Rs are important therapeutic targets for a range of sedative, anxiolytic, and hypnotic agents and are implicated in several diseases including epilepsy, anxiety, depression, and substance abuse. The GABA-A-R is a multimeric subunit complex. To date six ?s, four ?s and four ?s, plus alternative splicing variants of some of these subunits, have been identified (Olsen and Tobin, 1990; Whiting et al., 1999; Ogris et al., 2004). Injection in oocytes or mammalian cell lines of cRNA coding for ?- and ?-subunits results in the expression of functional GABA-A-Rs sensitive to GABA. However, coexpression of a ?-subunit is required for benzodiazepine modulation. Phosphorylation of serine 408 and serine 409 within the ?3 subunit have been shown to be critical for the functional modulation of ?3 containing recombinant receptors (Brandon et al., 2000).

10 mM HEPES (pH 7.5), 150 mM NaCl, 100 µg per ml BSA and 50% glycerol.

0.5-1mg/ml, actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

Gamma-aminobutyric acid receptor subunit beta-3

Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane.

Boster Bio Anti-Phospho-GABAA Receptor beta3 (Ser408/409) Antibody (Catalog # P02617). Tested in WB applications. This antibody reacts with Mouse, Rat.