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Anti-Phospho-Synapsin I (Ser62,67) Syn1 Antibody

Anti-Phospho-Synapsin I (Ser62,67) Syn1 Antibody

ArtNr	BOS-P03794-2
Hersteller	Boster
Menge	100 ul
Kategorie	Neuroscience Molecular Targets for Neuroscience Antibodies Immunohistochemistry Western Blot Primary Antibodies
Typ	Antibody
Format	Liquid
Applikationen	WB
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus), Rat (Rattus norvegicus)
Host	Rabbit
Isotype	IgG
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	Brain protein 4.1 antibody, SYN 1 antibody, SYN 1a antibody, SYN 1b antibody, SYN I antibody, SYN1 antibody, SYN1_HUMAN antibody, SYN1a antibody, SYN1b antibody, Synapsin 1 antibody, Synapsin I antibody, Synapsin-1 antibody, Synapsin1 antibody, SynapsinI antibody, SYNI antibody
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Manufacturer - Category	Primary Antibodies
Storage Conditions	Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C. After date of receipt, stable for at least 1 year at -20°C.
Observed Molecular Weight	74097 MW
Clonality	Polyclonal
Application notes	Specific for endogenous levels of the ~78 kDa synapsin I doublet phosphorylated at Ser62, 67. Immunolabeling is blocked by preadsorption with the phosphopeptide used as antigen, but not by the corresponding non-phosphopeptide.
Application Details	WB: 1:1000
Manufacturer - Gene Name	SYN1
Gene Full Name	Synapsin-1
Background	Synapsin I plays a key role in synaptic plasticity in brain (Feng et al., 2002; Nayak et al., 1996). This effect is due in large part to the ability of the synapsins to regulate the availability of synaptic vesicles for release. The role of synapsin in synaptic plasticity and in synaptogenesis is regulated by phosphorylation (Jovanovic et al., 2001; Kao et al., 2002). Ser-549 along with Ser-62 and Ser-67 are the sites of Synapsin I that are phosphorylated by MAP kinase (Czernik et al., 1987; Jovanovic et al., 1996).
Immunogen	Synthetic phospho-peptide corresponding to amino acid residues surrounding Ser62/67 of rat synapsin, conjugated to keyhole limpet hemocyanin (KLH). Immunogen species is Rat.
Contents	10 mM HEPES (pH 7.5), 150 mM NaCl, 100 µg per ml BSA and 50% glycerol.
Purification	Prepared from pooled rabbit serum by affinity purification via sequential chromatography on phospho and non-phosphopeptide affinity columns.
Concentration	0.5-1mg/ml, actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.
Phospho Site	Phosphorylated, Ser62, 67
Manufacturer - Research Category	Cancer, Cancer Susceptibility, Epigenetics and Nuclear Signaling, Oncoproteins, Oncoproteins/Suppressors, Proto-Oncogenes, Transcription
Protein Name	Synapsin-1
Protein Function	Neuronal phosphoprotein that coats synaptic vesicles, binds to the cytoskeleton, and is believed to function in the regulation of neurotransmitter release. Regulation of neurotransmitter release. The complex formed with NOS1 and CAPON proteins is necessary for specific nitric-oxide functions at a presynaptic level.
Subcellular Localization	Cell junction, synapse. Golgi apparatus.
Short Description	Boster Bio Anti-Phospho-Synapsin I (Ser62, 67) Syn1 Antibody (Catalog # P03794-2). Tested in WB applications. This antibody reacts with Human, Mouse, Rat.
Description	Boster Bio Anti-Phospho-Synapsin I (Ser62, 67) Syn1 Antibody (Catalog # P03794-2). Tested in WB applications. This antibody reacts with Human, Mouse, Rat.
Predicted Reactivity	Bovine

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BOS-P03794-2-datasheet.pdf

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