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Anti-Phospho-p56Dok-2 (Tyr299) Antibody Europäischer Partner

ArtNr BOS-P07956
Hersteller Boster
Menge 100 ul
Kategorie
Typ Antibody
Format Liquid
Applikationen WB, IF, IHC
Specific against Human (Homo sapiens)
Host Rabbit
ECLASS 10.1 32160702
ECLASS 11.0 32160702
UNSPSC 12352203
Alias Docking protein 2;Downstream of tyrosine kinase 2;p56 (dok-2);DOK2;
Lieferbar
Manufacturer - Category
Primary Antibodies
Storage Conditions
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Observed Molecular Weight
45379 MW
Clonality
Polyclonal
Application Details
Predicted MW: 56kd

Western blotting: 1:500~1:1000

Immunohistochemistry: 1:50~1:100

Immunofluorescence: 1:100~1:200
Manufacturer - Gene Name
DOK2
Gene Full Name
Docking protein 2
Background
DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK2 may modulate the cellular proliferation induced by IL-4, as well as IL-2 and IL-3. May be involved in modulating Bcr-Abl signaling. Attenuates EGF-stimulated MAP kinase activation
Feng Cong, et, al. (1999) Mol. Cell. Biol ; 19: 8314 - 8325.
Serge Lemay, et, al. (2000) Mol. Cell. Biol ; 20: 2743 - 2754.
Ute Schaeper, et, al.(2000) J. Cell Biol ; 149: 1419.
Miyuki Honma, et, al. (2006) Genes Cells; 11: 143 - 151.
Immunogen
Peptide sequence around phosphorylation site of tyrosine 299 (G-E-Y(p)-A-V) derived from Human p56Dok-2.
Contents
Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification
Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
Concentration
1 mg/ml
Manufacturer - Research Category
Adapters, Cancer, Cytoplasmic, MAPK Pathway, Protein Phosphorylation, Ser/Thr Kinases, Signal Transduction, Tyrosine Kinases
Protein Function
DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK2 may modulate the cellular proliferation induced by IL-4, as well as IL-2 and IL-3. May be involved in modulating Bcr-Abl signaling. Attenuates EGF-stimulated MAP kinase activation (By similarity).
Short Description
Boster Bio Anti-Phospho-p56Dok-2 (Tyr299) Antibody (Catalog # P07956). Tested in WB, IHC, IF applications. This antibody reacts with Human.
Description
Boster Bio Anti-Phospho-p56Dok-2 (Tyr299) Antibody (Catalog # P07956). Tested in WB, IHC, IF applications. This antibody reacts with Human.
Tissue Specificity
Highly expressed in peripheral blood leukocytes, lymph nodes and spleen. Lower expression in thymus, bone marrow and fetal liver.

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

Menge: 100 ul
Lieferbar: In stock
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