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Anti-Bag1 Antibody

Anti-Bag1 Antibody

Hersteller	Boster
Kategorie	Oncology Neuroscience Neuroinflammation Protein Aggregation, Clearance & Misfolding Antibodies By Cell Type Blastoma Carcinoma Hematology Leukemia Lymphoma Myeloma Cell Biology Cell Status Apoptosis Immunohistochemistry Western Blot Immunocytochemistry Autophagy Primary Antibodies By Organ Colorectal Cancer Breast Cancer Testicular & Prostate Cancer
Typ	Antibody Polyclonal
Specific against	Human, Rat
Isotype	IgG
Format	Lyophilized
Applikationen	WB, IHC, ICC
Menge	100 ug/vial
Host	Rabbit
ArtNr	BOS-PA1392
Targets	BCL2
eClass 6.1	32160702
eClass 9.0	32160702
Lieferbar
Background	BAG family molecular chaperone regulator 1(BAG1) is a protein that in humans is encoded by the BAG1 gene. Human BAG1 is mapped to chromosome 9p12, a region associated with hereditary disorders that may involve developmental dysregulation of programmed cell death. The Bag1 protein is rich in glutamic acid residues. Its deduced 274-amino acid protein has a calculated molecular mass of 31 KD. Being the BCL-2-associated athanogene, Bag1 enhances the anti-apoptotic effects of BCL2 and represents a link between growth factor receptors and anti-apoptotic mechanisms.
Concentration	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Contents	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
Cross reactivity	No cross reactivity with other proteins
Description	Rabbit IgG polyclonal antibody for BAG family molecular chaperone regulator 1(BAG1) detection. Tested with WB, IHC-P, ICC in Human; Rat.
Gene full name	BAG family molecular chaperone regulator 1
Gene name	BAG1
Immunogen	A synthetic peptide corresponding to a sequence at the C-terminus of human Bag1(322-344aa DTVEQNICQETERLQSTNFALAE), different from the related mouse sequence by two amino acids.
MW	38779 MW
Predicted reactivity	Canine, Rabbit
Protein function	Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release. Inhibits the pro-apoptotic function of PPP1R15A, and has anti-apoptotic activity. Markedly increases the anti-cell death function of BCL2 induced by various stimuli.
Protein name	BAG family molecular chaperone regulator 1(BAG-1)
Purification	Immunogen affinity purified.
Recommended detection ystems	Boster recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (EK1002) for Western blot, and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (SV0002-1) for IHC(P) and ICC.
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Research category	\|cell biology\|apoptosis\|intracellular\|bcl2 family\| cancer\|invasion/microenvironment\|bcl 2 family\| cardiovascular\|atherosclerosis\|heart\|autophagy\|autophagosome\| metabolism\|pathways and processes\|metabolism processes\|autophagy and mitophagy\|cell death\|apoptotic markers
Sequence similarities	Contains 1 BAG domain.
Storage	At -20C for one year. After reconstitution, at 4C for one month. It can also be aliquotted and stored frozen at -20C for a longer time.Avoid repeated freezing and thawing.
Subcellular localization	Isoform 1: Nucleus. Cytoplasm. Isoform 1 localizes predominantly to the nucleus.
Tissue specificity	Isoform 4 is the most abundantly expressed isoform. It is ubiquitously expressed throughout most tissues, except the liver, colon, breast and uterine myometrium. Isoform 1 is expressed in the ovary and testis. Isoform 4 is expressed in several types of tumor cell lines, and at consistently high levels in leukemia and lymphoma cell lines. Isoform 1 is expressed in the prostate, breast and leukemia cell lines. Isoform 3 is the least abundant isoform in tumor cell lines (at protein level).

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