Vergleich

Mouse FOLR1/Alpha Fr ELISA Kit PicoKine®

Hersteller Boster
Kategorie
Typ Elisa-Kit
Specific against Mouse
Applikationen ELISA
Menge 96 wells/kit, with removable strips.
ArtNr BOS-EK1243
Targets FOLR2, FOLR1
eClass 6.1 32160605
eClass 9.0 32160605
Lieferbar
Manufacturers Product Category
PicoKine® ELISA Kits
Manufacturers Research Category
Cell Type Markers, Tags & Cell Markers, Tumor Associated
Short Description
Mouse FOLR1/Alpha Fr ELISA Kit PicoKine® (96 Tests). Quantitate Mouse Folr1 in cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA). Sensitivity: 10pg/ml.
Description
Mouse FOLR1/Alpha Fr ELISA Kit PicoKine® (96 Tests). Quantitate Mouse Folr1 in cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA). Sensitivity: 10pg/ml.
Background
Folate receptor 1 adult is a protein that in humans is encoded by the FOLR1 gene. The protein encoded by this gene is a member of the folate receptor (FOLR) family. It is mapped to 11q13.4. FOLR1 expression in Jurkat cells facilitated MBG or EBO entry, and FR-blocking reagents inhibited infection of MBG or EBO. This gene product is a secreted protein that either anchors to membranes via a glycosyl-phosphatidylinositol linkage or exists in a soluble form. The FOLR1 gene encodes the adult folate receptor, or folate-binding protein (FBP), which has a high affinity for folic acid and for several reduced folic acid derivatives, and mediates delivery of 5-methyltetrahydrofolate to the interior of cells. FOLR1 is also an important regulator of milk protein synthesis.
Gene Name
FOLR1
Application Details
Dilution ratio of 1:1, concentration in serum and plasma is around 100 pg/ml.
Immunogen
Expression system for standard: E.coli; Immunogen sequence: T25-S232
Cross-reactivity
There is no detectable cross-reactivity with other relevant proteins.
Sample Type
cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA).
Capture antibody|Detection antibody
monoclonal antibody from rat|polyclonal antibody from goat
Storage
Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)
Anticoagulant
heparin or EDTA
Gene Full Name
Folate receptor alpha
Molecular Weight
29449 MW
Protein Function
Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. Has high affinity for folate and folic acid analogs at neutral pH. Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release. Required for normal embryonic development and normal cell proliferation. Required for renal folate reabsorption..
Subcellular Localization
Cell membrane; Lipid-anchor, GPI-anchor. Secreted. Cytoplasmic vesicle. Cytoplasmic vesicle, clathrin-coated vesicle. Endosome. Apical cell membrane. Endocytosed into cytoplasmic vesicles and then recycled to the cell membrane (By similarity). Detected at proximal tubule apical membranes..
Tissue Specificity
Detected in kidney proximal tubules (at protein level)..
Protein Name
Folate receptor alpha

Hinweis: Die dargestellten Informationen und Dokumente (Bedienungsanleitung, Produktdatenblatt, Sicherheitsdatenblatt und Analysezertifikat) entsprechen unserem letzten Update und sollten lediglich der Orientierung dienen. Wir übernehmen keine Garantie für die Aktualität. Für spezifische Anforderungen bitten wir Sie, uns eine Anfrage zu stellen.

Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

Menge: 96 wells/kit, with removable strips.
Lieferbar: In stock
lieferbar

Lieferung vsl. bis 02.05.2024 

Vergleichen

Auf den Wunschzettel

Angebot anfordern

Lieferzeit anfragen

Technische Frage stellen

Bulk-Anfrage stellen

Fragen zum Produkt?