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Smad2 (Phospho-Ser467) Colorimetric Cell-Based ELISA Kit

Smad2 (Phospho-Ser467) Colorimetric Cell-Based ELISA Kit

ArtNr	BOS-EKC1959
Hersteller	Boster
Menge	1 kit, containing two 96-well plates and all necessary reagents
Kategorie	Neuroscience Neural Lineage Markers ELISA ELISA & Immunoassays ELISA Kits Immunoassay Neurodegeneration Markers
Typ	Elisa-Kit
Applikationen	ELISA
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus), Rat (Rattus norvegicus)
Sensitivity	>5000 cells
ECLASS 10.1	32160605
ECLASS 11.0	32160605
UNSPSC	41116126
Alias	JV18-1;MADH2;MADR2;Mad-related protein 2;Mothers against DPP homolog 2;Mothers against decapentaplegic homolog 2;Smad 2
Lieferbar
Manufacturer - Category	Cell-Based ELISA Kits
Storage Conditions	Store at 4°C for up to 6 months.
Observed Molecular Weight	52306 MW
Manufacturer - Gene Name	SMAD2
Gene Full Name	Mothers against decapentaplegic homolog 2
Sample Type	Cell lines
Protein Function	Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. May act as a tumor suppressor in colorectal carcinoma. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator.
Subcellular Localization	Cytoplasm. Nucleus. Cytoplasmic and nuclear in the absence of TGF-beta. On TGF-beta stimulation, migrates to the nucleus when complexed with SMAD4 (PubMed:9865696). On dephosphorylation by phosphatase PPM1A, released from the SMAD2/SMAD4 complex, and exported out of the nucleus by interaction with RANBP1 (PubMed:16751101, PubMed:19289081).
Short Description	The Smad2 (Phospho-Ser467) Cell-Based ELISA Kit is a convenient, lysate-free, high throughput and sensitive assay kit that can monitor Smad2 (Phospho-Ser467) protein expression profile in cells. The kit can be used for measuring the relative amounts of Smad2 (Phospho-Ser467) in cultured cells as well as screening for the effects that various treatments, inhibitors (ie. siRNA or chemicals), or activators have on Smad2 (Phospho-Ser467).
Description	The Smad2 (Phospho-Ser467) Cell-Based ELISA Kit is a convenient, lysate-free, high throughput and sensitive assay kit that can monitor Smad2 (Phospho-Ser467) protein expression profile in cells. The kit can be used for measuring the relative amounts of Smad2 (Phospho-Ser467) in cultured cells as well as screening for the effects that various treatments, inhibitors (ie. siRNA or chemicals), or activators have on Smad2 (Phospho-Ser467).
Tissue Specificity	Expressed at high levels in skeletal muscle, endothelial cells, heart and placenta.

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BOS-EKC1959-datasheet.pdf

BOS-EKC1959-safety-datasheet.pdf