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RAD17 (Phospho-Ser645) Colorimetric Cell-Based ELISA Kit

RAD17 (Phospho-Ser645) Colorimetric Cell-Based ELISA Kit

ArtNr	BOS-EKC1999
Hersteller	Boster
Menge	1 kit, containing two 96-well plates and all necessary reagents
Kategorie	Oncology By Cell Type ELISA ELISA & Immunoassays ELISA Kits Immunoassay Immunostaining
Typ	Elisa-Kit
Applikationen	ELISA
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus)
Sensitivity	>5000 cells
ECLASS 10.1	32160605
ECLASS 11.0	32160605
UNSPSC	41116126
Alias	Cell cycle checkpoint protein RAD17,hRad17,RF-C/activator 1 homolog,RAD17,R24L
Lieferbar
Manufacturer - Category	Cell-Based ELISA Kits
Storage Conditions	Store at 4°C for up to 6 months.
Molecular Weight	77055 MW
Gene Name	RAD17
Gene Full Name	Cell cycle checkpoint protein RAD17
Protein Function	Essential for sustained cell growth, maintenance of chromosomal stability, and ATR-dependent checkpoint activation upon DNA damage. Has a weak ATPase activity required for binding to chromatin. Participates in the recruitment of the RAD1-RAD9- HUS1 complex and RHNO1 onto chromatin, and in CHEK1 activation. May also serve as a sensor of DNA replication progression, and may be involved in homologous recombination.
Subcellular Localization	Nucleus. Phosphorylated form redistributes to discrete nuclear foci upon DNA damage.
Description	The RAD17 (Phospho-Ser645) Cell-Based ELISA Kit is a convenient, lysate-free, high throughput and sensitive assay kit that can monitor RAD17 (Phospho-Ser645) protein expression profile in cells. The kit can be used for measuring the relative amounts of RAD17 (Phospho-Ser645) in cultured cells as well as screening for the effects that various treatments, inhibitors (ie. siRNA or chemicals), or activators have on RAD17 (Phospho-Ser645).
Tissue Specificity	Overexpressed in various cancer cell lines and in colon carcinoma (at protein level). Isoform 2 and isoform 3 are the most abundant isoforms in non irradiated cells (at protein level).Ubiquitous at low levels. Highly expressed in testis, where it is expressed within the germinal epithelium of the seminiferous tubuli. Weakly expressed in seminomas (testicular tumors).
Sample Type	Cell lines

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

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BOS-EKC1999-datasheet.pdf

BOS-EKC1999-safety-datasheet.pdf